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Testing Status of Sodium Metavanadate M940043

 

CASRN: 13718-26-8

Formula: Na.O3-V

Synonyms/Common Names

  • Sodium metavanadate

Short-Term Toxicity

  • 14 days (Dosed-Water)  (C94043)  Completed 
    • Citation: Mutlu E, Cristy T, Graves SW, Hooth MJ, Waidyanatha S. Characterization of aqueous formulations of tetra- and pentavalent forms of vanadium in support of test article selection in toxicology studies. Environ Sci Pollut Res Int. 2017 Jan;24(1):405-416. https://doi.org/10.1007/s11356-016-7803-x. Epub 2016 Oct 10.Pubmed Abstract
    • Citation: Roberts GK, Stout MD, Sayers B, Fallacara DM, Hejtmancik MR, Waidyanatha S, Hooth MJ. Clarification and lessons learned for reporting studies with hydrates. Citation: Roberts et al., 2016. Toxicology Reports 3: 531-538. Toxicol Rep. 2017 Dec 30;5:207-208. https://doi.org/10.1016/j.toxrep.2017.12.023.
    • TOX-106 
      Toxicity Studies of Sodium Metavanadate (CASRN 13718-26-8) and Vanadyl Sulfate (CASRN 27774-13-6) Administered in Drinking Water to Sprague Dawley (Hsd:Sprague Dawley SD) Rats and B6C3F1/N Mice
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1/N
    • Dose: Rats and mice: 0, 125, 250, 500, 1000, or 2000 ppm.
  • 90 days (Dosed-Water)  (C94043)  Completed 
    • Citation: Mutlu E, Cristy T, Graves SW, Hooth MJ, Waidyanatha S. Characterization of aqueous formulations of tetra- and pentavalent forms of vanadium in support of test article selection in toxicology studies. Environ Sci Pollut Res Int. 2017 Jan;24(1):405-416. https://doi.org/10.1007/s11356-016-7803-x. Epub 2016 Oct 10.Pubmed Abstract
    • Citation: Roberts GK, Stout MD, Sayers B, Fallacara DM, Hejtmancik MR, Waidyanatha S, Hooth MJ. Clarification and lessons learned for reporting studies with hydrates. Citation: Roberts et al., 2016. Toxicology Reports 3: 531-538. Toxicol Rep. 2017 Dec 30;5:207-208. https://doi.org/10.1016/j.toxrep.2017.12.023.
    • TOX-106 
      Toxicity Studies of Sodium Metavanadate (CASRN 13718-26-8) and Vanadyl Sulfate (CASRN 27774-13-6) Administered in Drinking Water to Sprague Dawley (Hsd:Sprague Dawley SD) Rats and B6C3F1/N Mice
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1/N
    • Dose: Rats and mice: 0, 31.3, 62.5, 125, 250, or 500 ppm.

Genetic Toxicology

  • 3 months Micronucleus (Dosed-Water)  (G94043B)  Completed 
    • Rats: Harlan Sprague-Dawley
  • 3 months Micronucleus (Dosed-Water)  (G94043C)  Completed 
    • Mice: B6C3F1/N
  • Salmonella  (G94043)  Completed 
    •  Negative 

Organ Systems Toxicity

  • 28 days Immunotoxicity (Dosed-Water)  (I94043)  Report in Preparation 
    • Immunotoxicology Screening Study
    • Female Mice: B6C3F1/N
    • Dose: 0, 31.3, 62.5, 125, 250, or 500 ppm.