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Testing Status of 3,3,4,4,5-Pentachlorobiphenyl (PCB 126) M950120

CASRN: 57465-28-8

Formula: C12-H5-Cl5

Synonyms/Common Names

  • 1,1'-Biphenyl, 3,3',4,4',5-pentachloro- (9CI)
  • PCB 126

Short-Term Toxicity

  • GD 6 to PND 21 (Gavage)  (C95120)  Completed 
    • In Utero-PND 22 Exposure to PCB126
    • Citation: Mutlu E, Gao L, Collins LB, Walker NJ, Hartwell HJ, Olson JR, Sun W, Gold A, Ball LM, Swenberg JA. Polychlorinated biphenyls induce oxidative DNA adducts in female Sprague-Dawley rats. Chem Res Toxicol. 2016 Aug;29(8):1335-1344
    • Rats: Wistar Han
    • Dose: 0, 10, 50, or 250 ng/kg; 10/group.

Special Studies

  • Toxicokinetic Study (Gavage)  (S0624)  Completed 
    • Male and Female Rats [R]: Sprague Dawley
    • Dose: (gavage) 0, 3, 10, 30, 100, 300, 1000, 3000 ng/kg, females. Males to be used as sentinels [R].

Genetic Toxicology

  • Salmonella  (G95120)  Completed 
    • Lot/Batch:  130494


  • Microarray Analysis (Gavage)  (T95120)  Completed 
    • In Utero - PND 22 Exposure to PCB-126
    • Rats: Wistar Han
    • Dose: 0, 10, 50, or 250 ng/kg; 8 dams and 48 pups/group.