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Testing Status of Tamoxifen citrate M960002

CASRN: 54965-24-1

Formula: C26-H29-N-O.C6-H8-O7

Synonyms/Common Names

  • 2-(4-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-,(Z)-, 2-hydroxy-1,2,3-oropanetricarboxylate (1:1)(9CI)
  • Nolvadex
  • TMX
  • (Z)-(2-(4-(1,2-Diphenylbut-1-enyl)phenoxy)ethyl)dimethylammonium dihydrogen

Special Studies

  • Absorption Distribution Metabolism Excretion (Gavage; Intravenous)  (S0617)  Completed 
    • Female Rats [R]: F344/N
    • Dose: (gavage) 0.1 and 0.3 mg/kg, single administration. 0.1 and 0.3 mg/kg, repeated dose. 0.3 mg/kg, final dose only [R]. (intravenous) 0.3 mg/kg, single administration. 0.3 mg/kg, final dose only [R].
  • C. elegans  (S0885)  Completed 
    • C. elegans [CE]
    • Dose: feeding: (0, 2.5, 4, 6.3, 10, 16, 25, 40, 63, 100, 160, 250) uM. repro: (0, 2.5, 4, 6.3, 10, 16, 25, 40, 63, 100, 160, 250) uM. growth: (0, 2.5, 4, 6.3, 10, 16, 25, 40, 63, 100, 160, 250) uM.
  • Preliminary Toxicokinetic Study (Intravenous)  (S0598)  Completed 
    • Citation: Reproductive Toxicity of Tamoxifen Citrate (CAS No. 54965-24-1) Administered by Gavage to Sprague-Dawley Rats. August 8, 1997.
    • Male and Female Rats [R]: Harlan Sprague-Dawley
    • Dose: (intravenous) 300 ug/kg [R].
  • Toxicokinetic Study (Gavage)  (S0598)  Completed 
    • Citation: Reproductive Toxicity of Tamoxifen Citrate (CAS No. 54965-24-1) Administered by Gavage to Sprague-Dawley Rats. August 8, 1997.
    • Male and Female Rats [R]: Sprague Dawley
    • Dose: (gavage) 30, 300 ug/kg [R].
  • Toxicokinetic Study (Gavage; Intravenous)  (S0916)  Completed 
    • Female Rats [R]: Fischer 344
    • Dose: (gavage) 100, 300 ug/kg; 300 ug/kg [R]. (intravenous) 300 ug/kg [R].
  • Toxicokinetic Study (Gavage; Intravenous)  (S0917)  Completed 
    • Male and Female Rats [R]: Sprague Dawley
    • Dose: (gavage) 10, 100, 300 ug/kg [R]. (intravenous) 300 ug/kg [R].

Organ Systems Toxicity

  • 14 weeks Continuous Breeding (Legacy) (Gavage)  (RACB95003)  Completed 
    • Male and Female Rats: Sprague Dawley
    • Dose: 0, .003, .01, OR .03.