Testing Status of Propargyl alcohol M960126

CASRN: 107-19-7

Formula: C3-H4-O

Synonyms/Common Names

• Ethynyl carbinol
• Propynl alcohol
• 2-Propyn-1-ol (8CI, 9CI)

Short-Term Toxicity

• 2 weeks (Inhalation)  (C97008)  Completed 
  • Rats: F344/N; Mice: B6C3F1/N
  • Dose: R&M: 0, 31.25, 62.5, 125, 250, OR 500 PPM; 5/SEX/SPECIES.
• 13 weeks (Inhalation)  (C97008)  Completed 
  • Rats: F344/N; Mice: B6C3F1/N
  • Dose: R&M: 0, 4, 8, 16, 32, OR 64 PPM R: 20/SEX M: 10/SEX.

Long-Term Carcinogenicity

• 2 years (Inhalation)  (C97008)  Completed 
  • TR-552 (NIH Number: 08-5893)  (Peer Review Approval 05/17/2007A )
    Toxicology and Carcinogenesis Studies of Propargyl Alcohol (CASRN 107-19-7) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1/N
  • Dose: R: 0, 16, 32, OR 64 PPM M: 0, 8, 16, OR 32 PPM; 50/SEX/SPECIES.
  • Carcinogenesis Results
    • Male Rats Some Evidence 
    • Female Rats No Evidence 
    • Male Mice Some Evidence 
    • Female Mice Some Evidence 

Special Studies

• Absorption Distribution Metabolism Excretion (Gavage; Topical Application; Intravenous; Inhalation; Gavage; Intravenous; Inhalation)  (S0815)  Completed 
  • Male Rats [R]: F344/N; Male Mice [M]: B6C3F1
  • Dose: (gavage) 50 mg/kg [R,M]. (inhalation) one 6-hr nose-only @ 1 ppm; one 6-hr nose-only @ 100 ppm [R,M]. (intravenous) 1 mg/kg, single [R,M]. (dermal) 0.5 and 5 mg/kg or 0.05, 0.5 and 5 mg/kg [R].

Genetic Toxicology

• Micronucleus  (A41608)  Completed 
  • Mice: B6C3F1
  • Male Negative 
  • Female Equivocal 
• Salmonella  (A70312)  Completed 
  •  Positive