Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Endocrine disruptor (Ethinyl estradiol) M980043

CASRN: 57-63-6

Formula: C20-H24-O2

Synonyms/Common Names

  • Ethinyl estradiol (Endocrine disruptor)
  • 19-Nor-17-alpha-pregna-1,3,5(10)-trien-20-yne-3,17-diol

Short-Term Toxicity

  • 28 days (Dosed-Feed)  (C20721)  Completed 
    • Rats: Sprague Dawley

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C20721)  Completed 
    • TR-548 (NIH Number: 10-5889)  (Peer Review Approval 05/16/2007A )
      Toxicology and Carcinogenesis Studies of Ethinyl Estradiol (CASRN 57-63-6) in Sprague-Dawley Rats (Feed Studies)
    • Rats: Sprague Dawley
    • Dose: 0, 2, 10, or 50 ppb.
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
  • 2 years (Dosed-Feed)  (C20721B)  Completed 
    • F1T140
    • TR-548 (NIH Number: 10-5889)  (Peer Review Approval 05/16/2007A )
      Toxicology and Carcinogenesis Studies of Ethinyl Estradiol (CASRN 57-63-6) in Sprague-Dawley Rats (Feed Studies)
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 2, 10, or 50 ppb.
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats Equivocal Evidence 
  • 2 years (Dosed-Feed)  (C20721C)  Completed 
    • F3T21
    • TR-548 (NIH Number: 10-5889)  (Peer Review Approval 05/16/2007A )
      Toxicology and Carcinogenesis Studies of Ethinyl Estradiol (CASRN 57-63-6) in Sprague-Dawley Rats (Feed Studies)
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 2, 10, or 50 ppb.
    • Carcinogenesis Results
      • Male Rats Equivocal Evidence 
      • Female Rats Equivocal Evidence 

Organ Systems Toxicity

  • Multigenerational Screen (Dosed-Feed)  (MG96006)  Completed 
    • NIH Number: 10-5888
      Citation: Multigenerational Reproductive Toxicology Study of Ethinyl Estradiol (CASRN 57-63-6) in Sprague-Dawley Rats (Feed Studies)
    • Male and Female Rats
    • Dose: 0, 0.1, 1, 5, 25, 100, OR 200 PPM. 0, 1, 25, OR 200 PPM. 0, 1, 5, OR 500 PPM.
    • Reproductive Dose Range Finding (Completed)
      • Days of Treatment: 28 DAYS
      • Dose: 0, 0.1, 1, 5, 25, 100, OR 200 PPM
    • Immunotoxicity (Completed)
      • Days of Treatment: 4 WEEKS
      • Dose: 0, 1, 25, OR 200 PPM
    • Behavioral Toxicity (Completed)
      • Days of Treatment: 10 WEEKS
      • Dose: 0, 1, 5, OR 500 PPM
    • Multigeneration Reproductive Study (F0) (Completed)
      • Days of Treatment: 20 WEEKS
    • Multigeneration Reproductive Study (F1) (Completed)
      • Days of Treatment: 20 WEEKS
    • Multigeneration Reproductive Study (F2) (Completed)
      • Multigeneration Reproductive Study (F3) (Completed)
        • Days of Treatment: 20 WEEKS
      • Multigeneration Reproductive Study (F4) (Completed)
        • Days of Treatment: 20 WEEKS
      • Cancer Study (F1) (Completed)
        • Cancer Study (F3) (Completed)