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Testing Status of Ginseng M990057

CASRN: 50647-08-0

Synonyms/Common Names

  • Panax
  • Prosapogenin

Short-Term Toxicity

  • 2 weeks (Gavage)  (C20005)  Completed 
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R&M: 0, 0.125, 0.25, 0.5, 1.0, OR 2.0 G/KG; 5/SEX/SPECIES/DOSE.
  • 5 days (Gavage)  (C99057)  Completed 
    • 5-Day Transcriptomic Dose-Response Studies
    • Citation: Gwinn WM, Auerbach SS, Parham F, Stout MD, Waidyanatha S, Mutlu E, Collins B, Paules RS, Merrick BA, Ferguson S, Ramaiahgari S, Bucher JR, Sparrow B, Toy H, Gorospe J, Machesky N, Shah RR, Balik-Meisner MR, Mav D, Phadke DP, Roberts G, DeVito MJ. Evaluation of 5-day In Vivo Rat Liver and Kidney With High-throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes. Toxicol Sci. 2020 Aug 1;176(2):343-354. doi: https://doi.org/10.1093/toxsci/kfaa081.Pubmed Abstract
    • Rats: Harlan Sprague-Dawley
    • Dose: Male rats: 0, 39.1, 78.125, 156.25, 317.5, 625, 1250, 2500, or 5000 mg/kg; N=4.
  • 13 weeks (Gavage)  (C20005)  Completed 
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R&M: 0, 1, 2, 3, 4, OR 5 G/KG; R: 20/SEX/DOSE; M: 10/SEX/DOSE.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C20005)  Completed 
    • TR-567 (NIH Number: 10-5909)  (Peer Review Approval 11/19/2009A )
      Toxicology and Carcinogenesis Studies of Ginseng (CASRN 50647-08-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R&M: 0, 1.25, 2.5, OR 5.0 G/KG; 50/SEX/SPECIES/DOSE.
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 

Special Studies

  • Absorption Distribution Metabolism Excretion (in-vitro)  (S0940)  Completed 
    • Citation: Etheridge AS, Black SR, Patel PR, So J, Mathews JM. An in vitro evaluation of cytochrome P450 inhibition and P-glycoprotein interaction with goldenseal, Ginkgo biloba, grape seed, milk thistle, and ginseng extracts and their constituents. Planta Med. 2007 Jul;73(8):731-41. Epub 2007 Jul 5. PubMed PMID: 17611934.Pubmed Abstract
    • Human (Cell Lines) [HU]
    • Dose: (in-vitro) 0, 1, 10 um [HU].

Genetic Toxicology

  • Micronucleus  (A82446)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • 24 hours Micronucleus (in-vitro) Selected (G22008B)  
    • Human (Cell Lines)
  • Salmonella  (A04849)  Completed 
    •  Negative 
  • Salmonella  (A16457)  Completed 
    •  Negative 
  • 24 hours Salmonella (in-vitro) Selected (G22008)  

    Toxicogenomics

    • 5-day Transcriptome Sequencing (Gavage)  (T99057)  Completed 
      • Citation: Gwinn WM, Auerbach SS, Parham F, Stout MD, Waidyanatha S, Mutlu E, Collins B, Paules RS, Merrick BA, Ferguson S, Ramaiahgari S, Bucher JR, Sparrow B, Toy H, Gorospe J, Machesky N, Shah RR, Balik-Meisner MR, Mav D, Phadke DP, Roberts G, DeVito MJ. Evaluation of 5-day In Vivo Rat Liver and Kidney With High-throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes. Toxicol Sci. 2020 Aug 1;176(2):343-354. doi: https://doi.org/10.1093/toxsci/kfaa081.Pubmed Abstract
      • Rats: Harlan Sprague-Dawley