Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Kava kava extract M990058

CASRN: 9000-38-8

Synonyms/Common Names

  • Kava-Kava resin (8CI)
  • Piper methisticum extract

Short-Term Toxicity

  • 2 weeks (Gavage)  (C20007)  Completed 
    •   (Peer Review Approval 01/26/2011A ) Citation: Yamashita H, Hoenerhoff MJ, Peddada SD, Sills RC, Pandiri AR. Chemical exacerbation of light-induced retinal degeneration in F344/n rats in National Toxicology Program rodent bioassays. Toxicol Pathol. 2016 Aug;44(6):892-903
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R&M: 0, 0.125, 0.25, 0.5, 1.0, OR 2.0 G/KG; 5/SEX/SPECIES/DOSE.
  • 13 weeks (Gavage)  (C20007)  Completed 
    • Citation: Yamashita H, Hoenerhoff MJ, Peddada SD, Sills RC, Pandiri AR. Chemical exacerbation of light-induced retinal degeneration in F344/n rats in National Toxicology Program rodent bioassays. Toxicol Pathol. 2016 Aug;44(6):892-903
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R&M: 0, 0.125, 0.25, 0.5, 1.0, OR 2.0 G/KG; R: 20/SEX/DOSE; M: 10/SEX/DOSE.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C20007)  Completed 
    •   (Peer Review Approval 01/26/2011A ) Citation: Yamashita H, Hoenerhoff MJ, Peddada SD, Sills RC, Pandiri AR. Chemical exacerbation of light-induced retinal degeneration in F344/n rats in National Toxicology Program rodent bioassays. Toxicol Pathol. 2016 Aug;44(6):892-903
    • TR-571 (NIH Number: 11-5913)  (Peer Review Approval 01/26/2011A )
      Toxicology and Carcinogenesis Studies of Kava Kava Extract (CASRN 9000-38-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R: 0, 0.1, 0.3, OR 1.0 G/KG; M: 0, 0.25, 0.5, OR 1.0 G/KG; 50/SEX/SPECIES/DOSE.
    • Carcinogenesis Results
      • Male Rats Equivocal Evidence 
      • Female Rats No Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 

Special Studies

  • Absorption Distribution Metabolism Excretion (Gavage; Intravenous)  (S0828)  Completed 
    • Citation: Mathews JM, Etheridge AS, Black SR. Inhibition of human cytochrome P450 activities by kava extract and kavalactones. Drug Metab Dispos. 2002 Nov;30(11):1153-7.Pubmed Abstract
    • Male Rats [R]: F344/N
    • Dose: (gavage) 100 mg/kg [R]. (intravenous) 7 mg/kg [R].
  • Absorption Distribution Metabolism Excretion (Gavage; Intravenous; in-vitro)  (S0855)  Completed 
    • Citation: Mathews JM, Etheridge AS, Black SR. Inhibition of human cytochrome P450 activities by kava extract and kavalactones. Drug Metab Dispos. 2002 Nov;30(11):1153-7.Pubmed Abstract
    • Citation: Mathews JM, Etheridge AS, Valentine JL, Black SR, Coleman DP, Patel P, So J, Burka, LT. Pharmacokinetics and disposition of the kavalactone kawain: interaction with kava extract & kavalactones in vivo & in vitro. Drug Metab Dispos. 2005 Oct; 33(10): 1555-63. Epub 2005 Jul 20.Pubmed Abstract
    • Male and Female Rats [R]: F344/N; Human (Cell Lines) [HU]
    • Dose: (gavage) 0, 1, 10, 100 uM [R]. (intravenous) 0, 1, 10, 100 uM [R]. (in-vitro) 0, 1, 10, 100 uM [HU].

Genetic Toxicology

  • Micronucleus  (A53705)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • 24 hours Micronucleus (in-vitro) Selected (G99058B)  
    • Human (Cell Lines)
  • Salmonella  (A00186)  Completed 
    •  Negative 
  • Salmonella  (A88186)  Completed 
    •  Negative 
  • Salmonella (in-vitro) Selected (G99058)