Testing Status of Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super®; OTNE) M990091

CASRN: 54464-57-2

Related: 68155-66-8; 68155-67-9

Formula: C16-H26-O

Synonyms/Common Names

• 2-Acetyloctahydro-2,3,8,8-tetramethylnaphthalene
• Boisvelone
• Iso-E super

Short-Term Toxicity

• 13 weeks (Topical Application)  (C20307)  Completed 
  • TOX-92 (NIH Number: 16-5940)
    Toxicity Studies of Octahydro-tetramethyl-naphthalenyl-ethanone (OTNE) Administered Dermally to F344/NTac Rats and B6C3F1/N Mice
  • Rats: F344/NTac; Mice: B6C3F1
  • Dose: 0, 6.25:93.75, 12.5:87.5, 25:75, 50:50, or 100:0; 10/sex/species.

Special Studies

• Absorption Distribution Metabolism Excretion (Gavage)  (S0876)  Completed 
  • Citation: Waidyanatha S, Ryan K. Disposition of fragrance ingredient [14C]1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone in male Fisher rats following oral administration and dermal application. Xenobiotica. 2014 Aug;44(8):749-56. doi: 10.3109/00498254.2014.888489. Epub 2014 Feb 17.Pubmed Abstract
  • Male Rats [R]: F344/N; Female Mice [M]: B6C3F1
  • Dose: (gavage) 20, 30 mg/kg [R,M].

Genetic Toxicology

• Micronucleus  (F28470)  Completed 
  • Rats: F344/NTac
  • Male Negative 
  • Female Negative 
• Micronucleus  (F35719)  Completed 
  • Mice: B6C3F1
  • Male Equivocal 
  • Female Positive 
• Salmonella  (A39068)  Completed 
  •  Negative 
• Salmonella  (G99091)  Completed 
  •  Negative 

Organ Systems Toxicity

• varies Immunotoxicity (Topical Application)  (IMM20702)  Completed 
  • Female Mice: BALB/c
  • Dose: 0, 1, 2.5, 5, 10, or 20%.