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Testing Status of Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super®; OTNE) M990091

CASRN: 54464-57-2

Formula: C16-H26-O

Synonyms/Common Names

  • 2-Acetyloctahydro-2,3,8,8-tetramethylnaphthalene
  • Boisvelone
  • Iso-E super

Short-Term Toxicity

  • 13 weeks (Topical Application)  (C20307)  Completed 
    • TOX-92 (NIH Number: 16-5940)
      Toxicity Studies of Octahydro-tetramethyl-naphthalenyl-ethanone (OTNE) Administered Dermally to F344/NTac Rats and B6C3F1/N Mice
    • Rats: F344/NTac; Mice: B6C3F1
    • Dose: 0, 6.25:93.75, 12.5:87.5, 25:75, 50:50, or 100:0; 10/sex/species.

Special Studies

  • Absorption Distribution Metabolism Excretion (Gavage)  (S0876)  Completed 
    • Citation: Waidyanatha S, Ryan K. Disposition of fragrance ingredient [14C]1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone in male Fisher rats following oral administration and dermal application. Xenobiotica. 2014 Aug;44(8):749-56. doi: 10.3109/00498254.2014.888489. Epub 2014 Feb 17.Pubmed Abstract
    • Male Rats [R]: F344/N; Female Mice [M]: B6C3F1
    • Dose: (gavage) 20, 30 mg/kg [R,M].

Genetic Toxicology

  • Micronucleus  (F28470)  Completed 
    • Rats: F344/NTac
    • Male Negative 
    • Female Negative 
  • Micronucleus  (F35719)  Completed 
    • Mice: B6C3F1
    • Male Equivocal 
    • Female Positive 
  • Salmonella  (A39068)  Completed 
    •  Negative 
  • Salmonella  (G99091)  Completed 
    •  Negative 

Organ Systems Toxicity

  • varies Immunotoxicity (Topical Application)  (IMM20702)  Completed 
    • Female Mice: BALB/c
    • Dose: 0, 1, 2.5, 5, 10, or 20%.