National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/605

Nominations in Review 2001

Chemicals studied by the NTP are selected mainly on the basis of human exposure, production levels, chemical structure, and available toxicological data. Selection of an agent for a study does not imply that the agent is hazardous or a potential carcinogen in laboratory animals; likewise, an agent not selected for toxicological study by the Program should not be taken to mean that the agent is not potentially hazardous or potentially carcinogenic in laboratory rodents. Substances are identified by a common or generic name and CAS Registry No. where appropriate.

For information, questions or comments, contact:

Dr. Scott A. Masten
Director, Office of Nomination and Selection
Division of the National Toxicology Program
National Institute of Environmental Health Sciences

P.O. Box 12233, MD K2-02
Research Triangle Park, NC 27709
(919) 541-5710 (voice)
(301) 451-5599 (fax)

[Send Email]

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Apigenin
Substance
[CAS No.]
Nominated by Nominated for Rationale for Nomination ICCEC Recommendations
Apigenin
[520-36-5]
National Cancer Institute
 
  • genotoxicity testing
  • developmental toxicity testing
Naturally occurring flavonoid with potential oxidant and estrogenic activity; lack of toxicity information No toxicological studies due to low potential for toxicity and human exposure

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Bladderwrack
Substance
[CAS No.]
Nominated by Nominated for Rationale for Nomination ICCEC Recommendations
Bladderwrack
[68917-51-1],[84696-13-9]
National Cancer Institute


 

  • chemical characterization (iodine content)
  • short-term (subacute) toxicity
  • significant human exposure through use as a dietary supplement
  • safety concern due to potential thyroid stimulation
  • limited available toxicity information
Toxicological studies:
  • Chemical characterization (iodine content)
  • Subchronic toxicity testing with evaluation of reproductive parameters

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n -Butyl Bromide
Substance
[CAS No.]
Nominated by Nominated for Rationale for Nomination ICCEC Recommendations
n -Butyl bromide
[109-65-9]
National Cancer Institute
  • Subchronic toxicity testing
  • Reproductive toxicity testing
  • industrial chemical with significant production volume and human exposure potential
  • mutagenic
  • potential for carcinogenicity
  • lack of toxicity information
Consideration deferred pending receipt of manufacturers' voluntary testing plans

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Cylindrospermopsin
Substance
[CAS No.]
Nominated by Nominated for Rationale for Nomination ICCEC Recommendations
Cylindrospermopsin
[14345-90-8]
National Institute of Environmental Health Sciences Complete toxicological characterization
  • Cyanobacterial toxin with potential for widespread human exposure through drinking water
  • high acute toxicity
  • limited available toxicity information
Toxicological studies:
  • Complete toxicological characterization including chronic toxicity and carcinogenicity testing

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Dibenzofuran
Substance
[CAS No.]
Nominated by Nominated for Rationale for Nomination ICCEC Recommendations
Dibenzofuran
[132-64-9]
National Cancer Institute

 

  • genotoxicity testing
  • Subchronic toxicity testing
  • widespread human exposure as an environmental contaminant
  • potential for carcinogenicity
  • lack of toxicity information
No toxicological studies due to low commercial production volume and low potential for human exposure

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Diphenolic acid
Substance
[CAS No.]

 

Nominated by

 

Nominated for

 

Rationale for Nomination

 

ICCEC Recommendations

 

Diphenolic acid
[126-00-1]
National Cancer Institute
  • genotoxicity testing
  • Subchronic toxicity testing
  • industrial chemical with potential for increasing use
  • structurally related to bisphenol A
  • lack of toxicity information
No toxicological studies due to low commercial production volume and low potential for human exposure

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Epigallocatechin-3-gallate
Substance
[CAS No.]

 

Nominated by

 

Nominated for

 

Rationale for Nomination

 

ICCEC Recommendations

 

Epigallocatechin-3-gallate
[989-51-5]
National Cancer Institute
 
  • Genotoxicity battery
  • Subchronic toxicity
Major polyphenol in green tea and green tea extract dietary supplements; potential chemopreventive agent; limited available toxicity information Toxicological studies:
  • Genotoxicity testing
  • Subchronic toxicity testing
  • Consider testing green tea extract

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2-Ethylhexyl- p- Dimethylaminobenzoic Acid
Substance
[CAS No.]

 

Nominated by

 

Nominated for

 

Rationale for Nomination

 

ICCEC Recommendations

 

2-Ethylhexyl- p- dimethylaminobenzoic acid
[21245-02-3]
Private Individual
  • Dermal absorption and pharmacokinetics
  • Reproductive toxicity
  • Developmental toxicity (pre- and post-natal)
  • Subchronic dermal toxicity
  • high production volume chemical with industrial and consumer (sunscreen) uses
  • evidence for phototoxicity and testicular toxicity
  • limited available toxicity information
Toxicological studies:
  • Subchronic toxicity and developmental and reproductive toxicity testing by the dermal route of exposure
  • Phototoxicity and photocarcinogenicity testing

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Grape Seed and Pine Bark Extracts
Substance
[CAS No.]

 

Nominated by

 

Nominated for

 

Rationale for Nomination

 

ICCEC Recommendations

 

Grape seed and pine bark extracts National Cancer Institute
  • Genotoxicity (bacterial mutagenicity and mammalian micronucleus assays)
  • Subchronic toxicity
  • Reproductive toxicity
  • Teratogenicity
Significant human exposure through use as a dietary supplement; limited available toxicity information Toxicological studies:
  • Genotoxicity testing
  • Subchronic toxicity testing
  • Developmental and reproductive toxicity testing
  • Select a standardized commercial pine bark extract for study

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Metalworking Fluids
Substance
[CAS No.]

 

Nominated by

 

Nominated for

 

Rationale for Nomination

 

ICCEC Recommendations

 

Metalworking fluids National Institute for Occupational Safety and Health
  • In vitro, short-term in vivo and subchronic toxicity studies aimed at evaluating carcinogenic potential of multiple formulations
  • Carcinogenicity (inhalation) study of at least one formulation
  • high production volume
  • large number of occupationally-exposed workers
  • lack of carcinogenicity and chronic toxicity data
Toxicological studies:
  • In vitro, short-term in vivo and subchronic toxicity studies aimed at evaluating toxicity and carcinogenicity potential of multiple commercial formulations

Recommendations regarding further testing will be made after reviewing the results of NTP preliminary studies

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Methyl Soyate
Substance
[CAS No.]

 

Nominated by

 

Nominated for

 

Rationale for Nomination

 

ICCEC Recommendations

 

Methyl soyate
[67784-80-9]
National Cancer Institute
  • Genotoxicity testing
  • Subchronic toxicity testing by the dermal route of exposure
  • increasing production volume as an alternative fuel (biodiesel)
  • lack of toxicity information
Consideration deferred pending receipt of toxicity data development plans through existing or future regulatory programs

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Methyl Tetrahydrofuran
Substance
[CAS No.]
Nominated by Nominated for Rationale for Nomination ICCEC Recommendations
Methyl tetrahydrofuran
[96-47-9]
National Cancer Institute
  • Genotoxicity (bacterial mutagenicity and mammalian micronucleus assays)
  • Subchronic toxicity
  • Mechanistic studies (related to a 2-globulin)
  • Carcinogenicity in Tg.AC mice
Increasing use in alternative fuels; suspicion of toxicity and carcinogenicity based on structure; limited available toxicity information Toxicological studies
  • Genotoxicity testing
  • Short-term toxicity testing

Consider dermal and inhalation routes of exposure

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Polybrominated Diphenyl Ethers
Substance
[CAS No.]
Nominated by Nominated for Rationale for Nomination

 

ICCEC Recommendations

 

Polybrominated diphenyl ethers
  • Pentabromodiphenyl ether (technical)
    [32534-81-9]
  • Octabromodiphenyl ether (technical)
    [32536-52-0]
  • 2,2',4,4'- Tetrabromodiphenyl ether
    [5436-43-1]
  • 2,2',4,4',5- Pentabromodiphenyl ether
    [60348-60-9]
  • 2,2',4,4',5,5'- Hexabromodiphenyl ether
    [68631-49-2]
  • California Environmental Protection Agency
  • New York State Department of Environmental Conservation
  • Private Individuals
Toxicological characterization including genotoxicity and neurotoxicity
  • high production volume flame retardants
  • widespread human exposure occupationally and as environmental contaminants
  • persistent and bioaccumulative
  • evidence for toxicity but significant knowledge gaps remain
Toxicological studies:
  • subchronic toxicity, developmental neurotoxicity and chronic toxicity testing of selected individual congeners
  • no testing of technical mixture
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.