National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/604

Nominations in Review 2003

Chemicals studied by the NTP are selected mainly on the basis of human exposure, production levels, chemical structure, and available toxicological data. Selection of an agent for a study does not imply that the agent is hazardous or a potential carcinogen in laboratory animals; likewise, an agent not selected for toxicologic study by the Program should not be taken to mean that the agent is not potentially hazardous or potentially carcinogenic in laboratory rodents. Substances are identified by a common or generic name and CAS Registry No. where appropriate.

For information, questions or comments, contact:

Dr. Scott A. Masten
Director, Office of Nomination and Selection
Division of the National Toxicology Program
National Institute of Environmental Health Sciences

P.O. Box 12233, MD K2-02
Research Triangle Park, NC 27709
(919) 541-5710 (voice)
(301) 451-5599 (fax)

[Send Email]

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Acrylamide and Glycidamide
Substance
[CAS No.]
Nominated by Nominated for Rationale for Nomination ICCEC Recommendations
Acrylamide and Glycidamide
(additional information)
[79-06-1],[5694-00-8]
U.S Food and Drug Administration Toxicological characterization including toxicokinetic, mechanistic, and carcinogenicity studies Inadequate information available to accurately assess human health risks from exposure to acrylamide in foodstuffs; a properly designed well-conducted, GLP-compliant bioassay with appropriate ancillary studies is needed to provide dose response information and account for the food matrix through which humans are exposed Toxicological studies:
  • Toxicological characterization
  • Toxicokinetics
  • Mechanistic (hemoglobin adducts)
  • Carcinogenicity
  • Bioavailability from food and drinking water

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Antimony Trisulfide
Substance
[CAS No.]
Nominated by Nominated for Rationale for Nomination ICCEC Recommendations
Antimony trisulfide
[1345-04-6]
National Cancer Institute Chronic toxicity/ carcinogenicity Significant human exposure in occupational settings and suspicion of carcinogenicity Toxicological studies:
  • Chronic toxicity/ carcinogenicity

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Cadmium Telluride
Substance
[CAS No.]
Nominated by Nominated for Rationale for Nomination ICCEC Recommendations
Cadmium telluride
(additional information)
[1306-25-8]
  • U.S. Department of Energy
  • Brookhaven National Laboratory
  • National Renewable Energy Laboratory
  • First Solar, Inc.
  • Long-term oral and inhalation toxicity studies
  • Chemical disposition, metabolism, and pharmacokinetic studies
  • potential for widespread applications in photovoltaic energy generation
  • anticipated increase in human exposures
  • further data needed to address health and safety issues related to manufacture and use
Toxicological studies:
  • Toxicological characterization
  • Chemical disposition (oral and inhalation)

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Cedarwood oil, Virginia
Substance
[CAS No.]
Nominated by Nominated for Rationale for Nomination ICCEC Recommendations
Cedarwood oil, Virginia
[8000-27-9]
National Cancer Institute Subchronic toxicity
  • widespread occupational and consumer exposure
  • lack of basic toxicology data
Toxicological studies:
  • Toxicological characterization
  • Developmental toxicity

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Chondroitin Sulfate
Substance
[CAS No.]
Nominated by Nominated for Rationale for Nomination ICCEC Recommendations
Chondroitin sulfate
[9007-28-7]
[9082-07-9] (sodium salt)
National Cancer Institute

 

Chronic toxicity/ carcinogenicity alone and in combination with glucosamine Widespread long-term use as a dietary supplement and inadequate data to assess safety Toxicological studies:
  • Chronic toxicity/ carcinogenicity
  • Carcinogenicity of chondroitin sulfate and glucosamine combined

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Dimethylethanolamine
Substance
[CAS No.]
Nominated by Nominated for Rationale for Nomination ICCEC Recommendations
Dimethylethanolamine
[108-01-0]
National Institute of Environmental Health Sciences Toxicological characterization including toxicokinetic, reproductive and developmental toxicity, mechanistic, and carcinogenicity studies
  • potential for widespread human exposure to DMAE through its use in industrial and consumer products
  • inadequate toxicological database
  • some ethanolamines can interfere with choline uptake and utilization and may also generate nitrosamines
Toxicological studies:
  • Metabolism

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Drugs positive for QT Interval Prolongation/Induction of Torsade Proarrhythmia
Substance
[CAS No.]
Nominated by Nominated for Rationale for Nomination ICCEC Recommendations
Drugs positive for QT Interval Prolongation/Induction of Torsade Proarrhythmia
[No CAS No.]
U.S Food and Drug Administration Non-clinical safety pharmacology studies of both problematic and non-problematic drugs in the conscious canine telemetry model to better establish the sensitivity and specificity of this in vivo model system for evaluating the property of a test agent to prolong QT interval at relevant exposures in humans QT interval prolongation and torsade de pointes is a high priority cause for concern in drug development and regulatory safety evaluation; a clear definition of the strengths, limitations, and future performance characteristics of the canine telemetry model for pre-clinical safety assessment is needed Initiate a study program to develop in vitro and in vivo test systems for assessing QT interval prolongation

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Glucosamine
Substance
[CAS No.]
Nominated by Nominated for Rationale for Nomination ICCEC Recommendations
Glucosamine
[3416-24-8]
National Cancer Institute Chronic toxicity/ carcinogenicity alone and in combination with chondroitin sulfate Widespread long-term use as a dietary supplement and inadequate data to assess safety Toxicological studies:
  • Chronic toxicity/ carcinogenicity
  • Carcinogenicity of chondroitin sulfate and glucosamine combined

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Nanoscale Materials
Substance
[CAS No.]
Nominated by Nominated for Rationale for Nomination ICCEC Recommendations
Nanoscale materials
[No CAS No.]
Rice University Center for Biological and Environmental Nanotechnology Toxicological characterization of several representative classes of nanomaterials Intense current and anticipated future research and development focus; further studies and development of appropriate toxicological methods are needed to adequately assess health effects Toxicological studies:
  • Size- and composition-dependent biological disposition of nanocrystalline fluorescent semiconductor materials
  • Toxicological characterization of high aspect ratio carbon nanomaterials
  • Role of particle core and surface composition in the immunotoxicity of the above listed materials
  • Phototoxicity of representative metal oxide nanoparticles

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trans-Resveratrol
Substance
[CAS No.]
Nominated by Nominated for Rationale for Nomination ICCEC Recommendations
trans-Resveratrol
[501-36-0]
National Institute of Environmental Health Sciences Toxicological characterization
  • widespread human exposure from natural dietary sources and use of dietary supplements
  • suspicion of toxicity based on estrogenic and genotoxic activity
  • insufficient data available to characterize safety
Toxicological studies:
  • Toxicological characterization
  • Carcinogenicity
  • Reproductive toxicity

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Tetrabromobisphenol A
Substance
[CAS No.]
Nominated by Nominated for Rationale for Nomination ICCEC Recommendations
Tetrabromobisphenol A
[79-94-7]
National Institute of Environmental Health Sciences Toxicological characterization including neurodevelopmental toxicity and carcinogencity studies High production volume, widespread human exposure and suspicion of thyroid toxicity/tumorigenicity Toxicological studies:
  • Toxicological characterization
  • Neurodevelopmental toxicity
  • Carcinogencity

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Tetrabromobisphenol A bis(2,3-dibromopropyl ether)
Substance
[CAS No.]
Nominated by Nominated for Rationale for Nomination ICCEC Recommendations
Tetrabromobisphenol A bis(2,3-dibromopropyl ether)
[21850-44-2]
National Institute of Environmental Health Sciences
  • Toxicological characterization
  • In vivo genotoxicity
  • High production volume
  • little toxicity data available
  • suspicion of carcinogenic potential due to 2,3-dibromo-1-propanol substructure
Toxicological studies:
  • Toxicological characterization
  • In vivo genotoxicity
  • Metabolism
  • Carcinogencity

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Tungsten
Substance
[CAS No.]
Nominated by Nominated for Rationale for Nomination ICCEC Recommendations
Tungsten
[7440-33-7]
National Center for Environmental Health Toxicological characterization including carcinogenicity Important industrial materials; insufficient data to assess human health implications of elevated urinary tungsten levels Toxicological studies:
  • Toxicological characterization
  • Carcinogenicity
Studies should focus on a representative soluble tungsten compound

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4-Phenylcyclohexene
Substance
[CAS No.]
Nominated by Nominated for Rationale for Nomination ICCEC Recommendations
4-Phenylcyclohexene
[4994-16-5]
Private Individuals Toxicological characterization including genotoxicity and neurotoxicity Present in indoor environments primarily from carpet emissions; concern that it has not been adequately tested for potential health effects No toxicological studies at this time due to low suspicion of hazard based on available human exposure and toxicity information
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.