National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/316

Nominations in Review 2004

Chemicals studied by the NTP are selected mainly on the basis of human exposure, production levels, chemical structure, and available toxicological data. Selection of an agent for a study does not imply that the agent is hazardous or a potential carcinogen in laboratory animals; likewise, an agent not selected for toxicologic study by the Program should not be taken to mean that the agent is not potentially hazardous or potentially carcinogenic in laboratory rodents. Substances are identified by a common or generic name and CAS Registry No. where appropriate.

* Note: A recommendation for "toxicological characterization" in this table includes studies for genotoxicity, subchronic toxicity, and chronic toxicity/carcinogenicity, as determined to be appropriate during the conceptualization and design of a research program to address toxicological data needs. Though other types of studies (e.g. metabolism and disposition, immunotoxicity, reproductive/developmental toxicity) may be conducted as part of a complete toxicological characterization, these types of studies are not listed unless they were specifically recommended.

For information, questions or comments, contact:

Dr. Scott A. Masten
Director, Office of Nomination and Selection
Division of the National Toxicology Program
National Institute of Environmental Health Sciences

P.O. Box 12233, MD K2-02
Research Triangle Park, NC 27709
(919) 541-5710 (voice)
(301) 451-5599 (fax)

[Send Email]

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Bitter orange extract
Substance[CAS No.] Nominated by Rationale for Nomination ICCEC Recommendations
Bitter orange extract
[No CAS No.]
Private Individual Consumer exposure through increasing dietary supplement use; suspicion of toxicity; lack of adequate toxicity data Developmental toxicity:
  • Physiological responses (e.g. cardiovascular and cerebrovascular) via telemetry
  • Subchronic toxicity
  • Toxicokinetics (of constituents)
  • Studies alone and in combination with caffeine
  • Studies in rats and possibly miniature-pigs

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n-Butyl glycidyl ether
Substance[CAS No.] Nominated by Rationale for Nomination ICCEC Recommendations
n-Butyl glycidyl ether
[2426-08-6]
National Institute of Environmental Health Sciences Suspicion of toxicity based on structural features; positive results in genetic toxicity studies; substantial potential for human exposure and a lack of chronic toxicity data Toxicological studies:
  • Toxicological characterization including reproductive toxicity, carcinogenicity, and analysis of urinary metabolites
  • Coordinate with voluntary data development activities of the U.S. EPA

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Di-(2-ethylhexyl)phthalate
Substance[CAS No.] Nominated by Rationale for Nomination ICCEC Recommendations
Di-(2-ethylhexyl)phthalate
[117-81-7]
U.S. Food and Drug Administration Long-term risks associated with medical exposures of infants to DEHP have not been clearly elucidated; significant knowledge gaps on the toxicokinetics and effects in fetal and neonatal primates of intravenous DEHP exposure; further studies will better define risks and benefits of utilizing non-DEHP-containing products Tiered research program to address:
  • Quantitative studies of toxicokinetics and biotransformation following intravenous exposure in neonatal male non-human primates
  • Assessment of toxicokinetics, reproductive and immune endpoints following acute and subchronic intravenous exposure to neonatal male rats and nonhuman primates

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Ionic liquids
Substance[CAS No.] Nominated by Rationale for Nomination ICCEC Recommendations
Ionic liquids
  • 1-Butyl-3-methylimidazolium chloride
    [79917-90-1]
  • 1-Butyl-1-methylpyrrolidinium chloride
    [479500-35-1]
  • N-Butylpyridinium chloride
    [1124-64-7]
University of Alabama Center for Green Manufacturing Widespread interest as replacements for volatile organic compounds (VOCs) in various applications; lack of toxicity data Toxicological studies:
  • Toxicological characterization
  • Coordinate research program with the U.S. EPA

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Perfluorinated compounds
Substance[CAS No.] Nominated by Rationale for Nomination ICCEC Recommendations
Perfluorinated compounds class study
[Multiple CAS Nos.]
U.S. Environmental Protection Agency Presumed widespread human exposure; known toxicity of certain class members; insufficient information to assess hazard/risk across entire structural class Toxicological studies:
  • Tiered research program to include pharmacokinetics, mechanistic, reproductive toxicity, and carcinogenicity studies

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Stachybotrys chartarum
Substance[CAS No.] Nominated by Rationale for Nomination ICCEC Recommendations
Stachybotrys chartarum
[67892-26-6]
  • Private Individual
  • National Institute of Environmental Health Sciences
Public concern regarding potential non-infectious adverse health effects of fungal exposures in indoor environments; inadequate toxicological data available evaluating potential systemic toxicity from long-term exposure to this organism under relevant exposure scenarios Toxicological studies:
  • Toxicological characterization including immunotoxicity

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Tungsten trioxide and fibrous tungsten suboxides
Substance[CAS No.] Nominated by Rationale for Nomination ICCEC Recommendations
Tungsten trioxide and fibrous tungsten suboxides
[1314-35-8]
National Cancer Institute Important industrial raw materials; one of several metals that may form toxic fibrous "whiskers"; carcinogenic potential of tungsten (vs. cemented tungsten carbide) is not adequately characterized Toxicological studies:
  • Toxicological characterization
  • Genotoxicity
  • Characterize fiber stability and biopersistence
  • In vitro toxicity to lung cells
  • Comparative intratracheal toxicity studies with a known hazardous fiber
  • Further studies including carcinogenicity will be considered following completion of above

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Butylparaben
Substance[CAS No.] Nominated by Rationale for Nomination ICCEC Recommendations
Butylparaben
[94-26-8]
National Institute of Environmental Health Sciences Widespread use in foods, cosmetics, and pharmaceuticals; potential reproductive toxicant; lack of adequate toxicity data Defer:
  • Pending further review of data on estrogen receptor binding, pharmacokinetics, dose-response of male reproductive effects, and human exposure

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Decane
Substance[CAS No.] Nominated by Rationale for Nomination ICCEC Recommendations
Decane
[124-18-5]
National Cancer Institute Widespread industrial use and environmental occurrence as air pollutant; suspicion of carcinogenicity but no adequate carcinogenicity study available Defer:
  • Pending review of industry voluntary data development activities coordinated by the U.S. EPA

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Undecane
Substance[CAS No.] Nominated by Rationale for Nomination ICCEC Recommendations
Undecane
[1120-21-4]
National Cancer Institute Widespread industrial use and environmental occurrence as air pollutant; suspicion of carcinogenicity but no adequate carcinogenicity study available Defer:
  • Pending review of industry voluntary data development activities coordinated by the U.S. EPA
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