National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/21158

Nominations in Review 2006

Substances Recommended for Study:

Substances for Which No Study is Recommended at this Time:

Chemicals studied by the NTP are selected mainly on the basis of human exposure, production levels, chemical structure, and available toxicological data. Selection of an agent for a study does not imply that the agent is hazardous or a potential carcinogen in laboratory animals; likewise, an agent not selected for toxicologic study by the Program should not be taken to mean that the agent is not potentially hazardous or potentially carcinogenic in laboratory rodents. Substances are identified by a common or generic name and CAS Registry No. where appropriate.

* Note: A recommendation for "toxicological characterization" in this table includes studies for genotoxicity, subchronic toxicity, and chronic toxicity/carcinogenicity, as determined to be appropriate during the conceptualization and design of a research program to address toxicological data needs. Though other types of studies (e.g. metabolism and disposition, immunotoxicity, reproductive/developmental toxicity) may be conducted as part of a complete toxicological characterization, these types of studies are not listed unless they were specifically recommended. Preliminary study recommendations are developed and refined by the nominator, NTP staff, and the ICCEC.

For information, questions or comments, contact:

Dr. Scott A. Masten
Director, Office of Nomination and Selection
Division of the National Toxicology Program
National Institute of Environmental Health Sciences

P.O. Box 12233, MD K2-02
Research Triangle Park, NC 27709
(919) 541-5710 (voice)
(301) 451-5599 (fax)

[Send Email]

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Arbutin

Substance
[CAS No.]

Nominated by

Nomination Rationale
(Principles*)

Preliminary Study Recommendations

Arbutin
[497-76-7]
National Institute of Environmental Health Sciences Consumer exposure through food, cosmetics and dietary supplements; lack of adequate toxicological data; suspicion of toxicity based on chemical structure (1, 6)
  • In vitro and in vivometabolism and disposition studies
  • In vitro and in vivogenotoxicity studies
  • Emphasis on understanding gastrointestinal metabolism and disposition, identifying experimental animal model representative of humans, and development of appropriate biomarkers

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tert-Butylacrylamide

Substance
[CAS No.]

Nominated by

Nomination Rationale
(Principles*)

Preliminary Study Recommendations

tert-Butylacrylamide
[107-48-4]
National Cancer Institute High production volume; potential worker and consumer exposures; lack of adequate toxicological data; suspicion of toxicity based on chemical structure (1, 6, 7)
  • Metabolism and disposition studies
  • Subchronic toxicity studies
  • Mammalian genotoxicity studies
  • Coordinate with voluntary data development activities of the Extended HPV (EHPV) Program

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Ceric oxide

Substance
[CAS No.]

Nominated by

Nomination Rationale
(Principles*)

Preliminary Study Recommendations

Ceric oxide
[1306-38-3]
National Institute of Environmental Health Sciences Widespread industrial use and potential for increasing exposure; demonstrated pulmonary toxicity; lack of toxicity data for nanoscale form (1, 6, 7)
  • Toxicological characterization including chemical disposition and toxicokinetics
  • Comparative inhalation toxicity studies of microscale and nanoscale forms
  • Dermal penetration studies

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Diazonaphthoquinone derivatives

Substance
[CAS No.]

Nominated by

Nomination Rationale
(Principles*)

Preliminary Study Recommendations

Diazonaphthoquinone derivatives:
  • Sodium 1,2-naphthoquinone-2- diazide-5-sulfonate
    [2657-00-3]
  • 2,3,4-Trihydroxybenzophenone tris(1,2-naphthoquinonediazide -5-sulfonate)
    [5610-94-6]
  • 2,3,4-Trihydroxybenzophenone 1,2-naphthoquinonediazide-5- sulfonate
    [68510-93-0]
National Institute of Environmental Health Sciences Moderate production volume; potential worker exposures from use in photolithography processes; lack of adequate toxicological data (1, 6, 7)
  • In vitro toxicity studies evaluating genotoxicity, immunotoxicity and phototoxicity
  • Dermal penetration studies

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3-Dimethylaminopropyl methacrylamide

Substance
[CAS No.]

Nominated by

Nomination Rationale
(Principles*)

Preliminary Study Recommendations

3-Dimethylaminopropyl methacrylamide
[5205-93-6]
National Cancer Institute High production volume; potential worker and consumer exposures; lack of adequate toxicological data; demonstrated toxicity in short-term studies (1, 6, 7)
  • Metabolism and disposition studies
  • Genotoxicity studies
  • Subchronic toxicity studies
  • Coordinate with voluntary data development activities through the Extended HPV (EHPV) Program

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Flame retardants

Substance
[CAS No.]

Nominated by

Nomination Rationale
(Principles*)

Preliminary Study Recommendations

Flame retardants: Consumer Project Safety Commission Anticipated increased use in upholstered furniture and bedding and potential consumer exposures from these uses; insufficient toxicity data to assess potential health risks (1, 6, 7) See individual recommendations
Antimony trioxide
[1309-64-4]
   
  • Chronic toxicity studies (oral route)
  • Consider studies of nanoscale form if used in or released during flame retardant applications
Decabromodiphenyl oxide
[1163-19-5]
   
  • Developmental neurotoxicity studies
  • Studies only to be performed if adequate private sector study not identified or planned
Tris(chloropropyl) phosphate, mixture of four isomers
[13674-84-5; 76025-08-6; 76649-15-5; 6145-73-9]
   
  • Subchronic and chronic toxicity studies (oral route)
  • Studies to focus on commercial mixture or major isomers present in commercially used mixtures
Phosphonic acid, (3-((hydroxymethyl) amino)-3- oxopropyl)-, dimethyl ester
[20120-33-6]
   
  • Subchronic and chronic toxicity studies (oral route)
  • Dermal absorption studies
Tris(hydroxymethyl) phosphine oxide
[1067-12-5]
   
  • Subchronic and chronic toxicity studies (oral route)
  • Dermal absorption studies
Aromatic phosphates:
  • tert-Butylphenyl diphenyl phosphate
    [56803-37-3]
  • 2-Ethylhexyl diphenyl phosphate
    [1241-94-7]
  • Isodecyl diphenyl phosphate
    [29761-21-5]
  • Phenol, isopropylated, phosphate (3:1)
    [68937-41-7]
  • Tricresyl phosphate
    [1330-78-5]
  • Triphenyl phosphate
    [115-86-6]
    For one or more representative aromatic phosphates:
  • Subchronic and chronic toxicity studies (oral route)
  • Neurotoxicity and/or developmental neurotoxicity studies
  • Coordinate with U.S. EPA to pursue additional testing by manufacturers

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Gypsum, natural and synthetic forms

Substance
[CAS No.]

Nominated by

Nomination Rationale
(Principles*)

Preliminary Study Recommendations

Gypsum, natural and synthetic forms
[13397-24-5]
Mount Sinai-Irving J. Selikoff Center for Occupational and Environmental Medicine

Operative Plasterers' and Cement Masons' International Association of the United States and Canada

 
Widespread worker exposures in numerous occupations and to the general population after destruction of the World Trade Centers in 2001; limited toxicity data to assess potential health risks (1, 2, 3, 6)
  • Short-term pulmonary toxicity studies
  • Comparative studies of intratracheal vs. inhalation routes of administration
  • Studies are of relatively low priority given low suspicion of toxicity

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N-methyl-3-oxobutanamide

Substance
[CAS No.]

Nominated by

Nomination Rationale
(Principles*)

Preliminary Study Recommendations

N-methyl-3-oxobutanamide
[20306-75-6]
National Cancer Institute High production volume; potential worker and environmental exposures; lack of adequate toxicological data (1, 6, 7)
  • In vitro and in vivo genotoxicity studies
  • Include structurally-related diketene compounds and N-phenyl derivatives

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Phenoxyethyl acrylate

Substance
[CAS No.]

Nominated by

Nomination Rationale
(Principles*)

Preliminary Study Recommendations

Phenoxyethyl acrylate
[48145-04-6]
National Cancer Institute High production volume; potential worker and consumer exposures; lack of adequate toxicological data (1, 6, 7) Defer pending voluntary data submission through the Extended HPV (EHPV) Program

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Trifluoromethylbenzene

Substance
[CAS No.]

Nominated by

Nomination Rationale
(Principles*)

Preliminary Study Recommendations

Trifluoromethylbenzene
[98-08-8]
National Cancer Institute High production volume and potential for increased use; potential worker exposures; lack of adequate toxicological data; demonstrated toxicity in short-term studies (1, 6, 7) Defer pending review of:
  1. production data through the 2006 Toxic Substances Control Act (TSCA) Inventory Update Rule, and
  2. Organization for Economic Cooperation and Development (OECD) Screening Information Data Sets (SIDS) program output
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.