National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/34144

Nominations in Review 2008 (Fall)

Substances studied by the NTP are selected primarily on the basis of known or anticipated human exposure, production levels, suspicion of toxicity based on chemical structure or existing health effects data, availability of toxicological data, and extent of public concern. Selection of a substance for study does not imply that the substance is hazardous or a potential carcinogen in laboratory animals; likewise, when substances are not selected for toxicological evaluation by the Program, this should not be taken to mean that the substance is not potentially hazardous or potentially carcinogenic in laboratory animals. Nominated substances in the table below are identified by a common or generic name and CAS Registry No. where appropriate.

* Note: The terms "initial toxicological characterization" and "comprehensive toxicological characterization" in this table refer to the approximate scope of a research program to address toxicological data needs. The types of toxicological studies that would be considered by NTP staff during the conceptualization and design of a research program for each are:

  • Initial toxicological characterization: biomolecular screening, in vitro mechanistic, in vitro and in vivo genotoxicity, absorption, disposition, metabolism, and elimination, and short-term repeat dose (2-4 weeks) in vivo studies
  • Comprehensive toxicological characterization: all of the aforementioned plus subchronic toxicity (13-26 weeks), chronic toxicity (1-2 years), carcinogenicity in conventional or genetically modified rodent models, organ systems toxicity (immunotoxicity, reproductive and developmental toxicity, neurotoxicity), in vivo mechanistic, toxicokinetics, and other special studies as appropriate (e.g. chemistry, toxicogenomics, phototoxicity).

 

Learn more about NTP Study Types.

For information, questions or comments, contact:

Dr. Scott A. Masten
Director, Office of Nomination and Selection
Division of the National Toxicology Program
National Institute of Environmental Health Sciences

P.O. Box 12233, MD K2-02
Research Triangle Park, NC 27709
(919) 541-5710 (voice)
(301) 451-5599 (fax)

[Send Email]

 

 

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Bisphenol AF
Substance
[CAS No.]
Nominated by Nomination Rationale
(Principles)
Preliminary Study Recommendations
Bisphenol AF
[1478-61-1]
National Institute of Environmental Health Sciences Moderate production and use in polymer synthesis; short-term studies suggest potential for endocrine disruption and adverse reproductive effects; lack of adequate toxicity data
  • Comprehensive toxicological characterization

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Dimethylamine borane
Substance
[CAS No.]
Nominated by Nomination Rationale
(Principles)
Preliminary Study Recommendations
Dimethylamine borane
[74-94-2]
National Institute for Occupational Safety and Health Possible contact sensitizer and systemic toxicant but insufficient evidence as determined by the NIOSH Dermal Subject Matter Expert Workgroup
  • Dermal absorption studies
  • Skin sensitization studies
  • Subchronic dermal toxicity studies with neurotoxicity and behavioral assessments

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Ethylene glycol 2-ethylhexyl ether
Substance
[CAS No.]
Nominated by Nomination Rationale
(Principles)
Preliminary Study Recommendations
Ethylene glycol 2-ethylhexyl ether
[1559-35-9]
National Institute of Environmental Health Sciences High production volume; potential worker exposures; suspicion of toxicity based on chemical structure; lack of adequate toxicity data
  • Reproductive and developmental toxicity studies

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Hydroxyurea
Substance
[CAS No.]
Nominated by Nomination Rationale
(Principles)
Preliminary Study Recommendations
Hydroxyurea
[127-07-1]

 

  • National Institute of Environmental Health Sciences
  • Private Individual
Long term safety concern when used as therapy for sickle cell anemia; NTP Center for the Evaluation of Risks to Human Reproduction (CERHR) Expert Panel identified a critical data need for multi-generation experimental animal studies to assess the long-term effects of prenatal and postnatal exposures on postnatal development including developmental neurotoxicity, reproductive function, and carcinogenicity No experimental animal toxicity studies at this time; human studies currently being considered by the NIH and other federal agencies may address outstanding safety concerns

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L-beta-Methylaminoalanine
Substance
[CAS No.]
Nominated by Nomination Rationale
(Principles)
Preliminary Study Recommendations
L-beta-Methylaminoalanine
[15920-93-1]
National Institute of Environmental Health Sciences Natural product of cyanobacteria with localized and potentially widespread environmental occurrence; suspected risk factor for neurological disease(s); lack of adequate toxicity data
  • Absorption, distribution, metabolism, and elimination studies
  • Neurotoxicity studies
  • Biomolecular screening studies

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Triclosan
Substance
[CAS No.]
Nominated by Nomination Rationale
(Principles)
Preliminary Study Recommendations
Triclosan
[3380-34-5]
  • Private Individual
  • U.S. Food and Drug Administration
Widespread use in consumer products; frequent and long-term exposure for all age groups; lack of adequate toxicity data for dermal exposures
  • Carcinogenicity studies via dermal administration
  • Phototoxicity studies
  • Reproductive toxicity studies
 

Note:
Some documents on this page are provided in PDF (Portable Document Format) and may not be fully accessible to some readers. If you have difficulty accessing a document, please send email to the NTP Webmaster [ Send Email ] or call Dr. Scott Masten 919-541-5710 and identify documents/pages for which access is required.



NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.