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Nomination Summary for Plumbagin (N20003)

Nominated Substances: Plumbagin

Nomination Date: 10/25/1999

Nominator: NCI

Rationale: Plumbagin is a natural yellow pigment that may have toxic properties. Human exposure occurs primarily through its use in folk medicines & recently marketed dietary supplements. There is much evidence to suggest that plumbagin may have potential as a chemotherapeutic or chemopreventive agent. Plumbagin has been identified as a redox-cycling agent that also induces DNA cleavage and demonstrates reproductive toxicity.

NTP Principles: not specified

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