National Toxicology Program

National Toxicology Program

Nomination Summary for Black cohosh (N20034)

Black cohosh

Nominated Substances: Black Cohosh

Nomination Date: 05/31/2000

Nominator: NCI, NIEHS

Rationale: Black cohosh is a dietary supplement used for the treatment of menstrual and menopausal symptoms in women. Black cohosh appears to bind to estrogen receptors and causes luteinizing hormone suppression. No chronic studies in humans or animals demonstrating the safety of black cohosh were found.

NTP Principles: 2, 3, 5

Status: Selected

Agents and Status

The following information relates to the specific agent and may include history from earlier or later nominations for this same agent.

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CASRN: 84776-26-1

Agent Name: Black Cohosh

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.