Specific Substances: N,N-Dimethyl-p-toluidine
Nomination Date: 05/31/2000
Rationale: N,N-dimethyl-p-toluidine is a high production volume chemical that has the potential for widespread human exposure by inhalation and dermal contact from its use in dental materials and bone cements. DMPT belongs to a class of chemicals suspected of having carcinogenic activity; its parent compound, p-toluidine is listed as a confirmed animal carcinogen. It is mutagenic and genotoxic in several test systems. Information on chronic toxicity and carcinogenicity is very limited.
NTP Principles: 3