National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/nm-n20035

Nomination Summary for N,N-Dimethyl-p-toluidine (N20035)

N,N-Dimethyl-p-toluidine

Specific Substances: N,N-Dimethyl-p-toluidine

Nomination Date: 05/31/2000

Nominator: NCI

Rationale: N,N-dimethyl-p-toluidine is a high production volume chemical that has the potential for widespread human exposure by inhalation and dermal contact from its use in dental materials and bone cements. DMPT belongs to a class of chemicals suspected of having carcinogenic activity; its parent compound, p-toluidine is listed as a confirmed animal carcinogen. It is mutagenic and genotoxic in several test systems. Information on chronic toxicity and carcinogenicity is very limited.

NTP Principles: 3

Status: Selected


Agents and Status

The following information relates to the specific agent and may include history from earlier or later nominations for this same agent.

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CASRN: 99-97-8

Agent Name: N,N-Dimethyl-p-toluidine

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.