Nomination Summary for S-adenosylmethionine (N20037)
Nomination Date: 05/31/2000
Rationale: S-Adenoslymethionine (SAMe) is a popular dietary supplement used to treat osteoarthritis, depression, and liver disease. SAMe is a physiological methyl donor in all mammals. Hypomethylation is associated with epigenetic changes leading to carcinogenesis. It is not known if high doses of exogenously administered SAMe can cause adverse effects from methylation of DNA bases.
Agents and Status
The following information relates to the specific agent and may include history from earlier or later nominations for this same agent.
Agent Name: S-adenosylmethionine chloride
Agent Name: S-adenosylmethionine