National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/nm-n20039

Nomination Summary for Cylindrospermopsin (N20039)

Cylindrospermopsin

Nominated Substances: Cylindrospermopsin

Nomination Date: 08/02/2000

Nominator: NIEHS

Rationale: Cyanobacteria, a blue-green algae associated with eutrophication, and their toxins have been identified by the EPA as drinking water contaminants with high health research priority. Recent evidence suggests that cylindrospermopsin, a hepatotoxin produced by Cylindrospermopsis raciborskii, is a common toxin in Florida surface waters. It has been associated with a severe out break of disease in humans in Australia and South America. Cylindrospermopsin is nominated for toxicity and carcinogenicity studies based on its potential for widespread human exposure via drinking and recreational waters and the limited toxicity studies and lack of long-term studies of the toxin.

NTP Principles: 1, 2, 6

Status: Selected


Agents and Status

The following information relates to the specific agent and may include history from earlier or later nominations for this same agent.

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CASRN: 143545-90-8

Agent Name: Cylindrospermopsin

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.