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Nomination Summary for Cylindrospermopsin (N20039)

Nominated Substances: Cylindrospermopsin

Nomination Date: 08/02/2000

Nominator: NIEHS

Rationale: Cyanobacteria, a blue-green algae associated with eutrophication, and their toxins have been identified by the EPA as drinking water contaminants with high health research priority. Recent evidence suggests that cylindrospermopsin, a hepatotoxin produced by Cylindrospermopsis raciborskii, is a common toxin in Florida surface waters. It has been associated with a severe out break of disease in humans in Australia and South America. Cylindrospermopsin is nominated for toxicity and carcinogenicity studies based on its potential for widespread human exposure via drinking and recreational waters and the limited toxicity studies and lack of long-term studies of the toxin.

NTP Principles: 1, 2, 6

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