National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/nm-n20041

Nomination Summary for Local anesthetics & metabolites (N20041)

Local anesthetics & metabolites

Specific Substances: Bupivacaine, Bupivacaine hydrochloride, Etidocaine, Mepivicaine, Mepivicaine hydrochloride, Prilocaine, Prilocaine hydrochloride, Ropivacaine

Nomination Date: 09/00/2000

Nominator: NIEHS

Rationale: Local anesthetics have widespread clinical use and human exposure including prenatal/postnatal exposure. Some of these compounds may be metabolized to carcinogenic and neurotoxic intermediates. NIEHS has identified for nomination local anesthetics that contain the 2,6-xylidine or o-toludine substructure for metabolism and mutagenicity studies.

NTP Principles: 1, 2, 3, 7

Status: Selected


Agents and Status

The following information relates to the specific agent and may include history from earlier or later nominations for this same agent.

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CASRN: 38396-39-3

Agent Name: Bupivacaine

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CASRN: 14252-80-3

Agent Name: Bupivacaine hydrochloride

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CASRN: 36637-18-0

Agent Name: Etidocaine

  • No studies are available.

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CASRN: 96-88-8

Agent Name: Mepivicaine

  • No studies are available.

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CASRN: 1722-62-9

Agent Name: Mepivicaine hydrochloride

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CASRN: 721-50-6

Agent Name: Prilocaine

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CASRN: 1786-81-8

Agent Name: Prilocaine hydrochloride

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CASRN: 84057-95-4

Agent Name: Ropivacaine

  • No studies are available.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.