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Nomination Summary for Local anesthetics & metabolites (N20041)

Nominated Substances: Bupivacaine, Bupivacaine hydrochloride, Etidocaine, Mepivicaine, Mepivicaine hydrochloride, Prilocaine, Prilocaine hydrochloride, Ropivacaine

Nomination Date: 09/00/2000

Nominator: NIEHS

Rationale: Local anesthetics have widespread clinical use and human exposure including prenatal/postnatal exposure. Some of these compounds may be metabolized to carcinogenic and neurotoxic intermediates. NIEHS has identified for nomination local anesthetics that contain the 2,6-xylidine or o-toludine substructure for metabolism and mutagenicity studies.

NTP Principles: 1, 2, 3, 7


Agents and Status

The following information relates to the specific agent and may include history from earlier or later nominations for this same agent.


CASRN: 38396-39-3

Agent Name: Bupivacaine


CASRN: 14252-80-3

Agent Name: Bupivacaine hydrochloride


CASRN: 1722-62-9

Agent Name: Mepivicaine hydrochloride


CASRN: 721-50-6

Agent Name: Prilocaine


CASRN: 1786-81-8

Agent Name: Prilocaine hydrochloride