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Nomination Summary for Lemon oil & Lime oil (N20101)

Nominated Substances: Lemon oil, Lime oil, 5-Methoxypsoralen, Oxypeucedanin

Nomination Date: 10/10/2000

Nominator: FDA

Rationale: Lemon and lime oils are added as fragrances to cosmetic products including some products intended for use on sun-exposed skin. Studies have shown that lemon and lime oil are phototoxic. Safe use levels have been recommended for avoiding short-term phototoxicity, but long-term use and effects have not been addressed. The phototoxicity elicited by lemon and lime oils has been associated with naturally occurring furocoumarins. While the photogenotoxicity of 5- methoxypsoralen is well established, the photogenotoxicity of oxypeucedanin alone or in mixtures has not been assessed.

NTP Principles: 1, 2

Agents and Status

The following information relates to the specific agent and may include history from earlier or later nominations for this same agent.

CASRN: 8008-56-8

Agent Name: Lemon oil

CASRN: 8008-26-2

Agent Name: Lime oil

CASRN: 484-20-8

Agent Name: 5-Methoxypsoralen