National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/nm-n20102

Nomination Summary for D & C Red (no. 27 & 28) (N20102)

D & C Red (no. 27 & 28)

Specific Substances: D & C red no. 27, D&C Red No. 28

Nomination Date: 10/00/2000

Nominator: FDA

Rationale: The FDA nominated D & C Red 27 & 28 for percutaneous absorption and subsequent photocarcinogenicity studies if percutaneous absorption is significant. Concern about photocarcinogenicity is related to the photodynamic activity of these dyes. These dyes photosensitize the formation of reactive oxygen species and also photosensitize damage to DNA. Structurally related halogenated fluorescein dyes have been found to be photogenotoxic. There is a lack of long-term phototoxicity/photocarcinogenicity data.

NTP Principles: 2, 3, 7

Status: Selected


Agents and Status

The following information relates to the specific agent and may include history from earlier or later nominations for this same agent.

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CASRN: 13473-26-2

Agent Name: D & C red no. 27

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CASRN: 18472-87-2

Agent Name: D&C Red No. 28

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.