National Toxicology Program

National Toxicology Program

Nomination Summary for All-trans-retinyl palmitate (N20103)

All-trans-retinyl palmitate

Specific Substances: All-trans-retinyl palmitate

Nomination Date: 10/00/2000

Nominator: FDA

Rationale: Retinyl palmitate was nominated for phototoxicity and photocarcinogenicity testing based on the increasingly widespread use of this compound in cosmetic retail products for use on sun-exposed skin and the need to investigate the biochemical and histological cutaneous alterations elicited by retinyl palmitate and the association between topical application of retinoids and enhancement of photocarcinogenesis.

NTP Principles: 2, 3, 7

Status: Selected

Agents and Status

The following information relates to the specific agent and may include history from earlier or later nominations for this same agent.

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CASRN: 79-81-2

Agent Name: All-trans-retinyl palmitate

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.