National Toxicology Program

National Toxicology Program

Nomination Summary for Bitter orange (Citrus aurantum) (N20225)

Bitter orange (Citrus aurantum)

Specific Substances: Bitter orange Extract Mixture, p-Octopamine, p-Synephrine

Nomination Date: 07/17/2002

Nominator: Private Individual

Rationale: Consumer exposure through increasing dietary supplement use; suspicion of toxicity; lack of adequate toxicity data.

NTP Principles: 1, 3, 6

Status: Selected

Agents and Status

The following information relates to the specific agent and may include history from earlier or later nominations for this same agent.

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Agent Name: Bitter orange Extract Mixture

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CASRN: 104-14-3

Agent Name: p-Octopamine

  • No studies are available.

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CASRN: 94-07-5

Agent Name: p-Synephrine

  • No studies are available.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.