National Toxicology Program

National Toxicology Program

Nomination Summary for Mixture of anti-androgenic phthalates (N20611)

Mixture of anti-androgenic phthalates

Specific Substances: Butyl benzyl phthalate, Dibutyl Phthalate, Di(2-ethylhexyl) Phthalate

Nomination Date: 10/31/2005

Nominator: Center for the Evaluation of Risks to Human Reproduction (CERHR)

Rationale: Many toxicologically active phthalates appear to have a common mechanism of action. Concurrent exposure of the general population to multiple phthalates may pose a greater health risk than expected based on risk estimates derived from toxicology studies on individual phthalates. While the literature is rich with publications on DEHP, DBP, BBP and other phthalates, there is clearly insufficient literature on studies involving mixtures of phthalates to support a CERHR expert panel evaluation. The CERHR Core Committee recommended that this nomination be forwarded to the NTP testing program and the extramural research program to stimulate toxicology research and testing that would enable a cumulative risk evaluation to be undertaken for this class of compounds.

NTP Principles: not specified

Status: Selected

Agents and Status

The following information relates to the specific agent and may include history from earlier or later nominations for this same agent.

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CASRN: 85-68-7

Agent Name: Butyl benzyl phthalate

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CASRN: 84-74-2

Agent Name: Dibutyl Phthalate

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CASRN: 117-81-7

Agent Name: Di(2-ethylhexyl) Phthalate

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.