Nominated Substances: ortho-Phthalaldehyde
Nomination Date: 09/29/2006
Rationale: ortho-Phthalaldehyde (OPA) is marketed, sold and used as a "safe" replacement for glutaralaldehyde for sterilization of heat sensitive dental and medical devices. However, the toxicity of OPA has not been characterized and some studies suggest that OPA may pose occupational hazards, similar to those of glutaralaldehyde. Data are needed to define and document the potential hazard to healthcare workers handling OPA, so that appropriate guidelines and protections can be put into place.