National Toxicology Program

National Toxicology Program

Nomination Summary for Ortho-phthalaldehyde (N20703)


Specific Substances: ortho-Phthalaldehyde

Nomination Date: 09/29/2006

Nominator: NIOSH

Rationale: ortho-Phthalaldehyde (OPA) is marketed, sold and used as a "safe" replacement for glutaralaldehyde for sterilization of heat sensitive dental and medical devices. However, the toxicity of OPA has not been characterized and some studies suggest that OPA may pose occupational hazards, similar to those of glutaralaldehyde. Data are needed to define and document the potential hazard to healthcare workers handling OPA, so that appropriate guidelines and protections can be put into place.

NTP Principles: 1, 6, 7

Status: Selected

Agents and Status

The following information relates to the specific agent and may include history from earlier or later nominations for this same agent.

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CASRN: 643-79-8

Agent Name: ortho-Phthalaldehyde

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.