Nomination Summary for Dong quai (Angelica sinensis root [308068-61-3] and extract [299184-76-2]) (N20812)

Nominated Substances: 3-Butylidenephthalide [551-08-6], Dong quai Angelica sinensis root, Dong quai (Angelica sinensis root extract), Ferulic Acid [1135-24-6], Ligustilide [4431-01-0]

Nomination Date: 08/20/2008

Nominator: Private Individual

Rationale: Widespread use as a dietary supplement; suspicion of toxicity based on estrogenic activity and chemical structure; lack of adequate toxicity data

NTP Principles: not specified

Status: Selected


Agents and Status

The following information relates to the specific agent and may include history from earlier or later nominations for this same agent.


CASRN: 551-08-6

Agent Name: 3-Butylidenephthalide [551-08-6]

  • No studies are available.

CASRN: 308068-61-3

Agent Name: Dong quai Angelica sinensis root

  • No studies are available.

CASRN: 299184-76-2

Agent Name: Dong quai (Angelica sinensis root extract)


CASRN: 1135-24-6

Agent Name: Ferulic Acid [1135-24-6]

  • No studies are available.

CASRN: 4431-01-0

Agent Name: Ligustilide [4431-01-0]

  • No studies are available.