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Nomination Summary for Dong quai (Angelica sinensis root [308068-61-3] and extract [299184-76-2]) (N20812)

Nominated Substances: 3-Butylidenephthalide [551-08-6], Dong quai Angelica sinensis root, Dong quai (Angelica sinensis root extract), Ferulic Acid [1135-24-6], Ligustilide [4431-01-0]

Nomination Date: 08/20/2008

Nominator: Private Individual

Rationale: Widespread use as a dietary supplement; suspicion of toxicity based on estrogenic activity and chemical structure; lack of adequate toxicity data

NTP Principles: not specified


Agents and Status

The following information relates to the specific agent and may include history from earlier or later nominations for this same agent.


CASRN: 299184-76-2

Agent Name: Dong quai (Angelica sinensis root extract)