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Nomination Summary for Ethyl alcohol and Mammary Tumors in ICR Mice (N21104)

Nominated Substances: Ethanol

Nomination Date: 01/26/2011

Nominator: National Institute on Alcohol Abuse and Alcoholism, NIH

Rationale: Relationship between alcohol consumption and breast cancer in women is a major public health concern; ethanol is classified as Carcinogenic to Humans (Group 1) by IARC, at multiple target tissues including the female breast, and based almost entirely on epidemiologic data; inadequacies in design of experimental animal studies where mammary tumors were observed; need to assess potential for ethanol to cause mammary tumors under rigorously defined and controlled studies in multiple strains of mice differing in susceptibility to chemical-induced mammary carcinogenesis

NTP Principles: not specified

Agents and Status

The following information relates to the specific agent and may include history from earlier or later nominations for this same agent.

CASRN: 64-17-5

Agent Name: Ethanol