National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/nm-n21104

Nomination Summary for Ethyl alcohol and Mammary Tumors in ICR Mice (N21104)

Ethyl alcohol and Mammary Tumors in ICR Mice

Specific Substances: Ethanol

Nomination Date: 01/26/2011

Nominator: National Institute on Alcohol Abuse and Alcoholism, NIH

Rationale: Relationship between alcohol consumption and breast cancer in women is a major public health concern; ethanol is classified as Carcinogenic to Humans (Group 1) by IARC, at multiple target tissues including the female breast, and based almost entirely on epidemiologic data; inadequacies in design of experimental animal studies where mammary tumors were observed; need to assess potential for ethanol to cause mammary tumors under rigorously defined and controlled studies in multiple strains of mice differing in susceptibility to chemical-induced mammary carcinogenesis

NTP Principles: not specified

Status: Received


Agents and Status

The following information relates to the specific agent and may include history from earlier or later nominations for this same agent.

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CASRN: 64-17-5

Agent Name: Ethanol

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.