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Nomination Summary for Octrizole and Related Phenolic Benzotriazoles (N21204)

Nominated Substances: Benzenepropanoic acid, 3-(2H-benzotriazol-2-yl)-5-(1,1-dimethylethyl)- 4-hydroxy-, C7-9-branched and linear alkyl esters, Bisoctrizole [USAN], Phenolic Benzotriazoles (Drometrizole), Phenolic Benzotriazoles (Octrizole), Phenol, 2-(2H-benzotriazol-2-yl)-6-(1-methyl-1-phenylethyl)-4- (1,1,3,3-tetramethylbutyl)-, Phenolic Benzotriazoles (2-(2H-Benzotriazol-2-yl)phenol), Phenolic Benzotriazoles (2-(2H-benzotriazol-2-yl)-4,6-bis(1,1-dimethylpropyl)phenol), Phenolic Benzotriazoles (2-(2H-benzotriazol-2-yl)-4,6-bis(1-methyl-1-phenylethyl)phenol), Phenolic Benzotriazoles (2-(5-Chloro-2H-benzotriazol-2-yl)-4,6-bis(1,1-dimethylethyl)phenol), Phenolic Benzotriazoles, Phenolic Benzotriazoles (Bumetrizole), Tinuvin 1130

Nomination Date: 10/28/2011

Nominator: NIEHS

Rationale: High production volume and use as UV stabilizers in a wide variety of industrial and consumer products; possess physico-chemical properties that suggest persistence in the environment and potential to bioaccumulate; limited toxicological data yet reproductive and developmental effects data for several class members suggest potential hazard

NTP Principles: not specified


Agents and Status

The following information relates to the specific agent and may include history from earlier or later nominations for this same agent.


CASRN: 2440-22-4

Agent Name: Phenolic Benzotriazoles (Drometrizole)


CASRN: 3147-75-9

Agent Name: Phenolic Benzotriazoles (Octrizole)


CASRN: 10096-91-0

Agent Name: Phenolic Benzotriazoles (2-(2H-Benzotriazol-2-yl)phenol)


CASRN: 25973-55-1

Agent Name: Phenolic Benzotriazoles (2-(2H-benzotriazol-2-yl)-4,6-bis(1,1-dimethylpropyl)phenol)


CASRN: 70321-86-7

Agent Name: Phenolic Benzotriazoles (2-(2H-benzotriazol-2-yl)-4,6-bis(1-methyl-1-phenylethyl)phenol)


CASRN: 3864-99-1

Agent Name: Phenolic Benzotriazoles (2-(5-Chloro-2H-benzotriazol-2-yl)-4,6-bis(1,1-dimethylethyl)phenol)


CASRN: 3896-11-5

Agent Name: Phenolic Benzotriazoles (Bumetrizole)