National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/nm-n21205

Nomination Summary for Avastin (bevacizumab) (N21205)

Avastin (bevacizumab)

Specific Substances: Avastin (bevacizumab)

Nomination Date: 11/10/2011

Nominator: Private Individual

Rationale: Off-label use of bevacizumab for treating wet type macular degeneration by intravitreal injection has dramatically increased in opthalmology clinical practice. There is an urgent need to determine if this drug is carcinogenic, mutagenic or a reproductive toxicant, and thus whether it meets the NIOSH definition of a "hazardous drug" (http://www.cdc.gov/niosh/topics/hazdrug/) and should be added to the NIOSH hazardous drug list so that recommendations for safe handling and use can be implemented.

NTP Principles: not specified

Status: Received


Agents and Status

The following information relates to the specific agent and may include history from earlier or later nominations for this same agent.

Back to Top

CASRN: 216974-75-3

Agent Name: Avastin (bevacizumab)

  • No studies are available.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.