Nomination Summary for Estragole (N79475)
Nominated Substances: Estragole
Nomination Date: 09/00/1979
Rationale: Nominated due to its structural similarity to the known carcinogen, safrole, and preliminary carcinogenicity studies in which it induced significant incidences of hepatocellular carcinomas in preweanling mice following subcutaneous injections. Estragole has the potential for wide-spread human exposure since it is used as a food flavoring agent and as a fragrance.