National Toxicology Program

National Toxicology Program

Nomination Summary for Theophylline (N80349)


Specific Substances: Theophylline

Nomination Date: 03/00/1980

Nominator: NCI

Rationale: Theophylline was nominated by the NCI as part of a class study of purines. Pharmacologically, it acts as a smooth muscle relaxant & is used extensively to treat bronchial asthma and emphysema. Theophylline is structurally similar to two purines which induce sarcomas when injected into rats. It has not been adequately studied despite its wide spread use, possible genetic toxicity and reported teratogenicity and testicular toxicity.

NTP Principles: Pre 1993 - 6

Status: Selected

Agents and Status

The following information relates to the specific agent and may include history from earlier or later nominations for this same agent.

Back to Top

CASRN: 58-55-9

Agent Name: Theophylline

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.