National Toxicology Program

National Toxicology Program

Nomination Summary for Oxazepam (N84333)


Specific Substances: Oxazepam

Nomination Date: 03/10/1986

Nominator: FDA

Rationale: Oxazepam is a metabolite of most benzodiazepines marketed. These drugs are among the most often prescribed in medicine and have been used primarily as antianxiety/hypnotics for many years. Most have some carcinogenicity studies, but none have complete two species bioassays similar to protocols currently followed by the NTP. Increased incidences of tumors in rats exposed to these drugs has been observed. However, it is not known whether the types of tumors observed are specific for each chemical or characteristic of certain benzodiazepine compounds.

NTP Principles: Pre 1993 - 3, 4

Status: Selected

Agents and Status

The following information relates to the specific agent and may include history from earlier or later nominations for this same agent.

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CASRN: 604-75-1

Agent Name: Oxazepam

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.