Specific Substances: 2,3,7,8-Tetrachlorodibenzo-p-dioxin
Nomination Date: 03/11/1991
Nominator: Private Individual
Rationale: Compelling evidence that ovarian hormones, probably estrogens, are required for hepatocarcinogenic actions of TCDD. Moreover, TCDD does not induce cell proliferation in the absence of estrogens. Since TCDD is considered the prototypical non-genotoxic carcinogen, it is an excellent candidate to study the relationship between cell proliferation and cancer.
NTP Principles: not specified