National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/nm-n91312

Nomination Summary for 4-Methylimidazole (N91312)

4-Methylimidazole

Specific Substances: 4-Methylimidazole

Nomination Date: 05/14/1991

Nominator: NCI

Rationale: Widespread use in food products; potential for widespread exposure. Lack of chronic toxicity data and suspicion of carcinogenicity. 4-methylimidazole is the starting material for the synthesis of cimetidine, a histamine antagonist used in ulcer therapy. In addition to occupational exposure, human exposure may result from exposure to tobacco smoke and processed foods. It has been found in molasses, caramel colored syrups, soy sauce, Worcestershire sauce and wine.

NTP Principles: Pre 1993 - 3, 8

Status: Selected


Agents and Status

The following information relates to the specific agent and may include history from earlier or later nominations for this same agent.

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CASRN: 822-36-6

Agent Name: 4-Methylimidazole

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.