National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/nm-n95004

Nomination Summary for p-Chloro-m-xylenol (PCMX) (N95004)

p-Chloro-m-xylenol (PCMX)

Nominated Substances: p-Chloro-m-xylenol (PCMX)

Nomination Date: 11/16/1994

Nominator: Private Individual

Rationale: Though PCMX has been used as an active antimicrobial agent in OTC topical health care antiseptic products for over 50 years, FDA has recommended that NIPA Laboratories conduct 90-day dose range-finding studies and lifetime carcinogenicity studies to confirm the safety of this product and to establish essential toxicological parameters. Because the concentration of PCMX in antiseptic products is low, only a small amount of PCMX is manufactured thus it will be difficult for NIPA to pay for these expensive long-term toxicological tests from funds generated from the sale of this "low volume" chemical. NIPA is requesting that NTP perform the tests requested by the FDA.

NTP Principles: not specified

Status: In Review/Pending


Agents and Status

The following information relates to the specific agent and may include history from earlier or later nominations for this same agent.

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CASRN: 88-04-0

Agent Name: p-Chloro-m-xylenol (PCMX)

  • No studies are available.
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