Specific Substances: Pyridostigmine bromide
Nomination Date: 07/24/1995
Rationale: There is significant human exposure to pyridostigmine bromide (PB) based on its reported use by 400,000 soldiers in the Gulf War as a pretreatment for exposure to nerve agents. There is concern about possible link of PB to the unexplained illness of Gulf War veterans. The studies of synergistic effects in animals would provide guidelines as to kinds of adverse effects that might be observed in humans exposed to PB in conjunction with other chemicals.
NTP Principles: not specified