Nomination Summary for Pyridostigmine bromide (N95029)

Nominated Substances: Pyridostigmine bromide

Nomination Date: 07/24/1995

Nominator: NCI

Rationale: There is significant human exposure to pyridostigmine bromide (PB) based on its reported use by 400,000 soldiers in the Gulf War as a pretreatment for exposure to nerve agents. There is concern about possible link of PB to the unexplained illness of Gulf War veterans. The studies of synergistic effects in animals would provide guidelines as to kinds of adverse effects that might be observed in humans exposed to PB in conjunction with other chemicals.

NTP Principles: not specified

Status: Deferred


Agents and Status

The following information relates to the specific agent and may include history from earlier or later nominations for this same agent.

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CASRN: 101-26-8

Agent Name: Pyridostigmine bromide