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Nomination Summary for Transgenic model evaluation (N95037)

Nominated Substances: p-Anisidine hydrochloride, Cyclosporin A, 2,4-Diaminotoluene (2,4-toluene diamine), Diethylstilbestrol, 8-Hydroxyquinoline, Melphalan, N-Methylolacrylamide, Methylphenidate hydrochloride, Resorcinol, Rotenone, 2,3,7,8-Tetrachlorodibenzo-p-dioxin, 2,6-Toluenediamine dihydrochloride (2,6-diaminotoluene dihydrochloride)

Nomination Date: 01/11/1995

Nominator: NIEHS

Rationale: The purpose of the proposed studies is to further examine the strengths and weaknesses of the Tg.AC and the p53+/- mouse models for identification of documented human and rodent carcinogens, and to explore their ability to provide information concerning the effective dosimetry for target organ mutation.

NTP Principles: 6

Status: Selected

Agents and Status

The following information relates to the specific agent and may include history from earlier or later nominations for this same agent.

CASRN: 20265-97-8

Agent Name: p-Anisidine hydrochloride

CASRN: 59865-13-3

Agent Name: Cyclosporin A

CASRN: 95-80-7

Agent Name: 2,4-Diaminotoluene (2,4-toluene diamine)

CASRN: 56-53-1

Agent Name: Diethylstilbestrol

CASRN: 148-24-3

Agent Name: 8-Hydroxyquinoline

CASRN: 148-82-3

Agent Name: Melphalan

CASRN: 924-42-5

Agent Name: N-Methylolacrylamide

CASRN: 298-59-9

Agent Name: Methylphenidate hydrochloride

CASRN: 108-46-3

Agent Name: Resorcinol

CASRN: 83-79-4

Agent Name: Rotenone

CASRN: 1746-01-6

Agent Name: 2,3,7,8-Tetrachlorodibenzo-p-dioxin

CASRN: 15481-70-6

Agent Name: 2,6-Toluenediamine dihydrochloride (2,6-diaminotoluene dihydrochloride)