National Toxicology Program

National Toxicology Program

Nomination Summary for t-Butyl formate (N96001)

t-Butyl formate

Specific Substances: t-Butyl formate

Nomination Date: 01/24/1996

Nominator: EPA

Rationale: T-butyl formate (TBF) is an environmental degradation product of methyl t-butyl ether (MTBE) the most widely used motor vehicle fuel oxygenate in the US. Public health complaints have been voiced re acute health effects related to exposure to evaporative and/or exhaust emissions from use of oxygenated gasoline during the winter oxygenate program. Several toxicity studies have been performed on MTBE and the US EPA is developing an extensive oxyfuels health research program. However, the EPA does not plan to pursue or require toxicity studies for TBF. TBF is nominated for NTP toxicity studies (subchronic, neurotoxicity, reproductive & developmental, pulmonary & immunotoxicity.)

NTP Principles: not specified

Status: Deferred

Agents and Status

The following information relates to the specific agent and may include history from earlier or later nominations for this same agent.

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CASRN: 762-75-4

Agent Name: t-Butyl formate

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.