Specific Substances: Phenothiazine
Nomination Date: 05/00/1997
Rationale: The nomination of phenothiazine is based on high production volumes and limited toxicological information. It is extensively used as a veterinary insecticide and antihelmintic in farm animals, but not humans or companion animals. (Zeneca, 11/19/97, indicated phenothiazine's current use is in industrial applications; no longer used for veterinary & agricultural applications.) Several phenothiazine-derivative psychopharmacological agents are marketed in the U.S. including chlorpromazine (Thorazine). It is not currently registered under FIFRA as a pesticide, but its veterinary use has been 'grandfathered' in. Phenothiazine is a photosensitizer in humans following oral administration. Oral consumption of high doses by humans has been reported to cause a number of effects including hemolytic anemia, toxic hepatitis, gastrointestinal and dermal irritation and kidney damage.