National Toxicology Program

National Toxicology Program

Nomination Summary for Chlorohydrins (N97023)


Specific Substances: 2-Chloroethanol (ethylene chlorohydrin), 2-Chloro-1-propanol

Nomination Date: 09/02/1997

Nominator: Private Individual

Rationale: Human epidemiology studies (Benson & Teta in British Journal of Industrial Medicine 50: 710-16, 1993) have shown an association between exposure to chlorohydrins and pancreatic lesions. In the NTP 13-week studies, pancreatic lesions were detected in rodents. However, the 2-year studies were conducted at levels below the dose at which the 13-week lesions were seen.

NTP Principles: not specified

Status: In Review/Pending

Agents and Status

The following information relates to the specific agent and may include history from earlier or later nominations for this same agent.

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CASRN: 107-07-3

Agent Name: 2-Chloroethanol (ethylene chlorohydrin)

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CASRN: 78-89-7

Agent Name: 2-Chloro-1-propanol

  • No studies are available.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.