Specific Substances: Ethyl silicate
Nomination Date: 09/30/1997
Rationale: Ethyl silicate's nomination is based on: 1) its potential for occupational exposures based on high production volume (7-20 million lbs) and estimate of potential worker exposures in the National Occupational Exposure Survey (NOES); 2) evidence of occupational exposures based on TLV and other literature documentation; 3) suspicion of carcinogenicity based on a significant increase in unscheduled DNA synthesis in rat hepatocytes, some positive genetic toxicity results in tests with structurally related chemicals, and evidence of kidney damage in animals following repeated (subacute) low level exposures; and 4) lack of a full battery of genetic toxicity tests and lack of chronic toxicity data.
NTP Principles: 2
Agents and Status
The following information relates to the specific agent and may include history from earlier or later nominations for this same agent.
Agent Name: Ethyl silicate