Nomination Summary for Polybrominated diphenyl ethers (N98021)
Nominated Substances: 2,2',4,4',5,5'-Hexabromodiphenyl ether (PBDE 153), Octabromodiphenyl ether, 2,2',4,4',5-Pentabromodiphenyl Ether, Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)], 2,2',4,4'-Tetrabromodiphenyl Ether
Nomination Date: 07/27/1998
Nominator: Private Individual
Rationale: Polybrominated diphenyl ethers were nominated based on their bioaccumulative properties, the ongoing production of PBDEs, and the possibility for widespread human exposure through the food chain. There is a lack of subchronic and chronic toxicity information and a suspicion of neuro-developmental toxicity. Studies in rodents have shown hyperplasia of the thyroid and a decrease in circulating thyroid hormone levels after exposure to technical mixtures of PBDEs.
Agents and Status
The following information relates to the specific agent and may include history from earlier or later nominations for this same agent.
Agent Name: 2,2',4,4',5,5'-Hexabromodiphenyl ether (PBDE 153)
Agent Name: Octabromodiphenyl ether
Agent Name: 2,2',4,4',5-Pentabromodiphenyl Ether
Agent Name: Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)]
Agent Name: 2,2',4,4'-Tetrabromodiphenyl Ether