National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-08002

Testing Status of Bisphenol AF - 08002

 

CASRN: 1478-61-1

Formula: C15-H10-F6-O2

Synonyms/Common Names

  • 2,2-Bis(4-hydroxyphenyl)perfluoropropane
  • BP-AF
  • BPAF
  • Phenol, 4,4'-(2,2,2-trifluoro-1-(trifluoromethyl)ethylidene)bis-

Known Uses

Moderate production and use in polymer synthesis.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 5 days (Gavage)  (C08002)  On Test 
    • 5-Day Transcriptomic Dose-Response Studies
    • Rats: Harlan Sprague-Dawley
    • Dose: Male rats: 0, 8, 16, 31.25, 62.5, 125, 250, 500, or 1000 mg/kg; N=4.

Modified One-Generation

  • Dose Range Finding (Dosed-Feed)  (MOG08002)  Completed 
    • Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 937.5, 1875, 3750, or 7500 ppm.
  • Developmental Toxicity (Dosed-Feed)  (MOG08002B)  Completed 
    • Modified One-Generation study of Bisphenol AF (BPAF; CAS No. 1478-61-1; MOG08002B) in Harlan Sprague-Dawley Rats Administered Via Dosed Feed
    • Rats: Harlan Sprague-Dawley
  • F0 Generation (Dosed-Feed)  (MOG08002B)  Completed 
    • Modified One-Generation study of Bisphenol AF (BPAF; CAS No. 1478-61-1; MOG08002B) in Harlan Sprague-Dawley Rats Administered Via Dosed Feed
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 338, 1125, or 3750 ppm.
  • Fertility Assessment (Dosed-Feed)  (MOG08002B)  Completed 
    • Modified One-Generation study of Bisphenol AF (BPAF; CAS No. 1478-61-1; MOG08002B) in Harlan Sprague-Dawley Rats Administered Via Dosed Feed
    • Rats: Harlan Sprague-Dawley
  • Maternal Transfer (Dosed-Feed)  (MOG08002B)  Completed 
    • Modified One-Generation study of Bisphenol AF (BPAF; CAS No. 1478-61-1; MOG08002B) in Harlan Sprague-Dawley Rats Administered Via Dosed Feed
    • Rats: Harlan Sprague-Dawley
  • 13-Week Subchronic (Dosed-Feed)  (MOG08002B)  Completed 
    • Modified One-Generation study of Bisphenol AF (BPAF; CAS No. 1478-61-1; MOG08002B) in Harlan Sprague-Dawley Rats Administered Via Dosed Feed
    • Rats: Harlan Sprague-Dawley

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (K08002)  Completed 
    • Citation: Final Study Report Absorption, Distribution, Metabolism, and Excretion (ADME) Studies of [14C]Bisphenol AF (CAS #1478-61-1) in Harlan Sprague Dawiey Rats (HSD) and B6C3F1/N Mice
    • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1; Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1
    • Dose: 3.4, 34, 340 mg/kg. 34 mg/kg.
  • Preliminary Toxicokinetic Study (Gavage; Intravenous)  (K08002B)  Report in Preparation 
    • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1; Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1
    • Dose: 3.4 mg/kg bwt. 34, 340 mg/kg bwt. PBSA11080 (mouse, plasma) 3.4 mg/kg bwt. PBSA11080 (mouse, plasma) 34, 340 mg/kg bwt.
  • Toxicokinetic Study (Gavage; Intravenous)  (K08002C)  On Test 
    • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N; Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N
    • Dose: 34 mg/kg. 34, 110 and 340 mg/kg.

Genetic Toxicology

  • 20 weeks Micronucleus (Dosed-Feed)  (G08002B)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Male Negative 
    • Female Negative 
  • Salmonella  (G08002)  Completed 
    •  Negative 

Organ Systems Toxicity

  • GD 6 - PND 96 Immunotoxicity (Dosed-Feed)  (I08002)  Report in Preparation 
    • Male and Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 250, 500, or 1000 ppm.
  • Utero-Lactational (In Utero)  (R08002)  Completed 
    • Rats: Harlan Sprague-Dawley

Toxicogenomics

  • 5 days Transcriptome Sequencing (Gavage)  (T08002)  Assigned 
    • 5-Day Transcriptomic Dose-Response Studies
    • Rats: Harlan Sprague-Dawley
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.