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Testing Status of Bisphenol AF 08002

 

CASRN: 1478-61-1

Formula: C15-H10-F6-O2

Synonyms/Common Names

  • 2,2-Bis(4-hydroxyphenyl)perfluoropropane
  • BP-AF
  • BPAF
  • Phenol, 4,4'-(2,2,2-trifluoro-1-(trifluoromethyl)ethylidene)bis-

Known Uses

Moderate production and use in polymer synthesis.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 5 days (Gavage)  (C08002)  Report Draft 
    • 5-Day Transcriptomic Dose-Response Studies
    • Rats: Harlan Sprague-Dawley
    • Dose: Male rats: 0, 8, 16, 31.25, 62.5, 125, 250, 500, or 1000 mg/kg; N=4.

Modified One-Generation

  • Dose Range Finding (Dosed-Feed)  (MOG08002)  Completed 
    • Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 937.5, 1875, 3750, or 7500 ppm.
  • Developmental Toxicity (Dosed-Feed)  (MOG08002B)  Completed 
    • Modified One-Generation study of Bisphenol AF (BPAF; CAS No. 1478-61-1; MOG08002B) in Harlan Sprague-Dawley Rats Administered Via Dosed Feed
    • Rats: Harlan Sprague-Dawley
  • F0 Generation (Dosed-Feed)  (MOG08002B)  Completed 
    • Modified One-Generation study of Bisphenol AF (BPAF; CAS No. 1478-61-1; MOG08002B) in Harlan Sprague-Dawley Rats Administered Via Dosed Feed
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 338, 1125, or 3750 ppm.
  • Fertility Assessment (Dosed-Feed)  (MOG08002B)  Completed 
    • Modified One-Generation study of Bisphenol AF (BPAF; CAS No. 1478-61-1; MOG08002B) in Harlan Sprague-Dawley Rats Administered Via Dosed Feed
    • Rats: Harlan Sprague-Dawley
  • Maternal Transfer (Dosed-Feed)  (MOG08002B)  Completed 
    • Modified One-Generation study of Bisphenol AF (BPAF; CAS No. 1478-61-1; MOG08002B) in Harlan Sprague-Dawley Rats Administered Via Dosed Feed
    • Rats: Harlan Sprague-Dawley
  • 13-Week Subchronic (Dosed-Feed)  (MOG08002B)  Completed 
    • Modified One-Generation study of Bisphenol AF (BPAF; CAS No. 1478-61-1; MOG08002B) in Harlan Sprague-Dawley Rats Administered Via Dosed Feed
    • Rats: Harlan Sprague-Dawley

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (K08002)  Completed 
    • Citation: Final Study Report Absorption, Distribution, Metabolism, and Excretion (ADME) Studies of [14C]Bisphenol AF (CAS #1478-61-1) in Harlan Sprague Dawiey Rats (HSD) and B6C3F1/N Mice
    • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1; Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1
    • Dose: 3.4, 34, 340 mg/kg. 34 mg/kg.
  • (K08002D)  Assigned 
    • Preliminary Toxicokinetic Study (Gavage; Intravenous)  (K08002B)  Report in Preparation 
      • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1; Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1
      • Dose: 3.4 mg/kg. 34 mg/kg. 34, 340 mg/kg.
    • Toxicokinetic Study (Gavage; Intravenous)  (K08002C)  On Test 
      • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N; Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N
      • Dose: 34 mg/kg. 34, 110 and 340 mg/kg.

    Genetic Toxicology

    • 20 weeks Micronucleus (Dosed-Feed)  (G08002B)  Completed 
      • Rats: Harlan Sprague-Dawley
      • Male Negative 
      • Female Negative 
    • Salmonella  (G08002)  Completed 
      •  Negative 

    Organ Systems Toxicity

    • GD 6 - PND 96 Immunotoxicity (Dosed-Feed)  (I08002)  Report in Preparation 
      • Male and Female Rats: Harlan Sprague-Dawley
      • Dose: 0, 250, 500, or 1000 ppm.
    • Utero-Lactational (In Utero)  (R08002)  Completed 
      • Rats: Harlan Sprague-Dawley

    Toxicogenomics

    • 5 days Transcriptome Sequencing (Gavage)  (T08002)  Assigned 
      • 5-Day Transcriptomic Dose-Response Studies
      • Rats: Harlan Sprague-Dawley