National Toxicology Program

National Toxicology Program

Testing Status of 2,3-Pentanedione - 08010


CASRN: 600-14-6

Formula: C5-H8-O2

Synonyms/Common Names

  • Acetyl propionyl
  • 2,3-Pentadione

Known Uses

Used As a Substitute for 2,3-butanedione. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 90 days (Inhalation)  (C08010)  Report Draft 
    • Rats: Wistar Han; Mice: B6C3F1
    • Dose: 0, 6.25, 12.5, 25, 50, or 100; R: 20/sex/conc; M: 10/sex/conc.

Genetic Toxicology

  • Micronucleus  (G08010B)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Micronucleus  (G08010)  Completed 
    • Rats: Wistar Han
    • Male Negative 
    • Female Negative 

Organ Systems Toxicity

  • Varies Immunotoxicity (Topical Application)  (I08010)  Completed 
    • Female Mice: BALB/c
    • Dose: 0, 1%, 2.5%, 5%, 10%, or 25%.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.