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Testing Status of 2,3-Pentanedione 08010

 

CASRN: 600-14-6

Formula: C5-H8-O2

Synonyms/Common Names

  • Acetyl propionyl
  • 2,3-Pentadione

Known Uses

Used As a Substitute for 2,3-butanedione. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 90 days (Inhalation)  (C08010)  Report in Preparation 
    • Citation: Morgan DL, Jokinen MP, Johnson CL, Price HC, Gwinn WM, Bousquet RW, Flake GP. Chemical reactivity and respiratory toxicity of the alpha-diketone flavoring agents: 2,3-butanedione, 2,3-pentanedione, and 2,3-hexanedione. Toxicol Pathol. 2016 Jul;44(5):763-783
    • Rats: Wistar Han; Mice: B6C3F1
    • Dose: 0, 6.25, 12.5, 25, 50, or 100; R: 20/sex/conc; M: 10/sex/conc.

Genetic Toxicology

  • Micronucleus  (G08010B)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Micronucleus  (G08010)  Completed 
    • Rats: Wistar Han
    • Male Negative 
    • Female Negative 

Organ Systems Toxicity

  • Varies Immunotoxicity (Topical Application)  (I08010)  Completed 
    • Female Mice: BALB/c
    • Dose: 0, 1%, 2.5%, 5%, 10%, or 25%.