National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-08032

Testing Status of Dong quai (Angelica sinensis root extract) - 08032

 

CASRN: 299184-76-2

Synonyms/Common Names

  • Dong quai

Known Uses

Widespread use as a dietary supplement; suspicion of toxicity based on estrogenic activity and chemical structure; lack of adequate toxicity data

Chemical Properties

Toxicity Effects (HSDB)

Planned Carcinogenicity/Toxicity

  • 14 days (Gavage) Selected (C08032)  
    • Mice: B6C3F1
  • 13 weeks (Gavage) Selected (C08032)  
    • Mice: B6C3F1

Modified One-Generation

  • 14 days Dose Range Finding (Gavage) Selected (MOG08032)  
    • Rats: Harlan Sprague-Dawley
  • Developmental Toxicity (Gavage) Selected (MOG08032B)  
    • Rats: Harlan Sprague-Dawley
  • F0 Generation (Gavage) Selected (MOG08032B)  
    • Rats: Harlan Sprague-Dawley
  • Fertility Assessment (Gavage) Selected (MOG08032B)  
    • Rats: Harlan Sprague-Dawley
  • Neurotoxicology Assessment (Gavage) Selected (MOG08032B)  
    • Rats: Harlan Sprague-Dawley
  • 90 days Subchronic (Gavage) Selected (MOG08032B)  
    • Rats: Harlan Sprague-Dawley

Toxicogenomics

  • Microarray Analysis (Gavage) Selected (T08032)  
    • Mice: B6C3F1
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.