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Testing Status of L-beta-Methylaminoalanine 08035

 

CASRN: 15920-93-1

Formula: C4-H10-N2-O2

Synonyms/Common Names

  • L-BMAA
  • 3-(Methylamino)-L-alanine

Known Uses

A neurotoxic non-protein amino acid produced naturally by cyanobacteria found in freshwater, marine and terrestrial ecosystems.

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (K08035)  Completed 
    • Citation: Waidyanatha S, Ryan K, Sanders JM, McDonald JD, Wegerski CJ, Doyle-Eisle M, Garner CE. Disposition of β-N-methylamino-l-alanine (L-BMAA), a neurotoxin, in rodents following a single or repeated oral exposure. Toxicol Appl Pharmacol. 2018 Jan 15;339:151-160. doi: 10.1016/j.taap.2017.12.008. Epub 2017 Dec 15.Pubmed Abstract
    • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1; Male Rats: Harlan Sprague-Dawley; Male Mice: B6C3F1
    • Dose: 1 mg/kg. 1, 10, 100 mg/kg.