National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-08036

Testing Status of Tris(4-chlorophenyl)methane - 08036

 

CASRN: 27575-78-6

Synonyms/Common Names

  • TCPMe

Known Uses

Production of synthetic high polymers and lightfast dyes for acrylic fibers. Occupational Exposure: Exposure may occur during manufacture of synthetic high polymers, lightfast dyes for acrylic fibers, anthelmintic drugs, and agrochemical formulations (e.g., DDT).

Chemical Properties

Toxicity Effects (HSDB)

Modified One-Generation

  • 10 days prior to mating - PND60 Dose Range Finding (Dosed-Feed)  (MOG08036)  Assigned 
    • Perinatal Dose Range-Finding MOG Study of Tris(4-chlorophenyl)methane
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 10, 50, 150, or 500 ppm.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (K08036)  Completed 
    • Citation: Amended Final Study Report Absorption, Distribution, Metabolism and Excretion (ADME) and Toxicokinetic (TK) Studies of Tris(4-Chlorophenyl)Methane (TCPME, CAS # 27575-78-6) and Tris(4-Chlorophenyl)Methanol (TCPMOH, CAS # 3010-80-8) in Harlan Sprague Dawley Rats (HSD) and B6C3F1/N Mice
    • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N; Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N

Genetic Toxicology

  • Salmonella  (G08036)  Completed 
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.