Testing Status of Pubertal Toxicity Studies 09008

 

CASRN: PUBERTALTOX

Formula: N/A

Secondary:

  • 57-63-6 - Endocrine disruptor (Ethinyl estradiol)
  • 72-43-5 - Endocrine disruptor (Methoxychlor)
  • 50471-44-8 - Endocrine disruptor (Vinclozolin)
  • 57-63-6 - Ethinyl estradiol
  • 13311-84-7 - Flutamide
  • 72-43-5 - Kid pest project (Methoxychlor)
  • 72-43-5 - Methoxychlor
  • 50-06-6 - Phenobarbital
  • 57-63-6 - Pubertal ethinyl estradiol study
  • 13311-84-7 - Pubertal flutamide study
  • 72-43-5 - Pubertal methoxychlor study
  • 50-06-6 - Pubertal phenobarbital study
  • 50471-44-8 - Pubertal vinclozolin study
  • 57-63-6 - Transgenic model evaluation (Ethinyl estradiol)
  • 50471-44-8 - Vinclozolin

Known Uses

Study to evaluate the sensitivity EPA Pubertal Protocol in detection of endocrine disrupting chemicals (vinclozolin, flutamide, phenobarbital, methoxychlor, ethinyl estradiol and phenobarbital)

Organ Systems Toxicity

  • PND range from 22 to 53/53 Continuous Breeding (Legacy) (Gavage)  (R09008)  Completed 
    • Citation: Pubertal Toxicity Study of Vinclozolin, Flutamide and Phenobarbital in Male Sprague Dawley Rats and Methyxychlor, Ethinyl Estradiol and Phenobarbital in Female Sprague Dawley Rats when Administered in Corn Oil by Oral Gavage
    • Male and Female Rats: Sprague Dawley
    • Dose: Vinclozolin (males): 0, 10, 30, or 100 mg/kg/day; Flutamide (males): 0, 25, or 50 mg/kg/day; Phenobarbital (males & females): 0, 25, 50, or 100 mg/kg/day; Methoxychor (females): 0, 12.5, 25, or 50 mg/kg/day; Ethinyl estradiol (females): 0, 0.0025, or 0.005 mg/kg/day; The vehicle control for both males and females was corn oil with only one control group per sex..