National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-09009

Testing Status of (+)-Usnic Acid - 09009

 

CASRN: 7562-61-0

Related: Usnic Acid (125-46-2)

Formula: C18-H16-O7

Synonyms/Common Names

  • 1,3(2H,9bH)-dibenzofurandione, 2,6-diacetyl-7,9-dihydroxy- 8,9b-dimethyl-, (9bR)-
  • D-Usnic acid

Known Uses

Preservative, active ingredient in medicinal products, marketed as a dietary supplement to promote weight loss

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Dosed-Feed)  (C20609)  Completed 
    • Rats: F344 (NCTR); Mice: B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-)
    • Dose: R: 0, 60 120, 360, 1250, or 2500 ppm in chow; M: 0, 30, 60, 180, 600, or 1200 ppm in chow.
  • 90 days (Dosed-Feed)  (C20609)  Completed 
    • Rats: F344 (NCTR); Mice: B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-)
    • Dose: R: 0, 30, 60, 120, 360, or 720 ppm; M: 0, 15, 30, 60, 180, or 360 ppm.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.