National Toxicology Program

National Toxicology Program

Testing Status of Tenofovir Disoproxil Fumarate (TDF) - 09014


CASRN: 202138-50-9

Formula: C19-H30-N5-O10-P.C4-H4-O4

Synonyms/Common Names

  • TDF
  • Tenofovir DF

Known Uses

Pharmaceutical used in the treatment of HIV (AIDS)

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • Preliminary Toxicokinetic Study (Gavage)  (K09014)  Report in Preparation 
    • Female Mice: CD-1 Reg.[Crl:CD1(ICR)]
    • Dose: 18.8, 37.5, 75 mg/kg.

Organ Systems Toxicity

  • GD 5 - PND 21 Teratology Pilot Studies (Gavage)  (R09014)  Report in Preparation 
    • Prenatal/Perinatal Dose Range-Finding
    • Female Mice: CD-1
    • Dose: 0, 75, 150, 300, or 600 mg/kg/day.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.